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Association of ABO and RhD blood groups with the risk of HIV infection
research-article
Author(s):
Genevieve Jacobs
1
,
*
,
,
Karin Van den Berg
1 ,
Marion Vermeulen
1 ,
Ronel Swanevelder
1 ,
Brian Custer
2
,
3 ,
Edward L. Murphy
2
,
3
Publication date (Electronic):
26 April 2023
Journal:
PLOS ONE
Publisher:
Public Library of Science
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Abstract
Naturally occurring antibodies against ABO antigens present in human sera have been shown to neutralize ABO-expressing HIV in vitro. We investigated associations between ABO and RhD blood groups and HIV infection among blood donors from all blood collection centers in eight of South Africa’s nine provinces. Whole blood donations collected from first time donors between January 2012 and September 2016 were tested for HIV RNA by nucleic acid testing and HIV antibody using third generation serology assays. ABO and RhD blood types were determined using automated technology. Odds ratios for the association between HIV positivity and ABO and RhD phenotypes were calculated using multivariable logistic regression analysis. We analyzed 515,945 first time blood donors and the overall HIV prevalence was 1.12% (n = 5790). After multivariable adjustment, HIV infection was weakly associated with RhD positive phenotype (OR = 1.15, 95% CI 1.00–1.33) but not with ABO blood group. The observed association with RhD positive phenotype was marginal and likely due to residual confounding by racial group but could serve to generate hypotheses for further studies.
Related collections
Most cited references17
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- Abstract: found
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Blood Groups in Infection and Host Susceptibility.
Laura Cooling (2015)
Blood group antigens represent polymorphic traits inherited among individuals and populations. At present, there are 34 recognized human blood groups and hundreds of individual blood group antigens and alleles. Differences in blood group antigen expression can increase or decrease host susceptibility to many infections. Blood groups can play a direct role in infection by serving as receptors and/or coreceptors for microorganisms, parasites, and viruses. In addition, many blood group antigens facilitate intracellular uptake, signal transduction, or adhesion through the organization of membrane microdomains. Several blood groups can modify the innate immune response to infection. Several distinct phenotypes associated with increased host resistance to malaria are overrepresented in populations living in areas where malaria is endemic, as a result of evolutionary pressures. Microorganisms can also stimulate antibodies against blood group antigens, including ABO, T, and Kell. Finally, there is a symbiotic relationship between blood group expression and maturation of the gastrointestinal microbiome.
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The relationship between blood groups and disease.
David J. Anstee (2010)
The relative contribution of founder effects and natural selection to the observed distribution of human blood groups has been debated since blood group frequencies were shown to differ between populations almost a century ago. Advances in our understanding of the migration patterns of early humans from Africa to populate the rest of the world obtained through the use of Y chromosome and mtDNA markers do much to inform this debate. There are clear examples of protection against infectious diseases from inheritance of polymorphisms in genes encoding and regulating the expression of ABH and Lewis antigens in bodily secretions particularly in respect of Helicobacter pylori, norovirus, and cholera infections. However, available evidence suggests surviving malaria is the most significant selective force affecting the expression of blood groups. Red cells lacking or having altered forms of blood group-active molecules are commonly found in regions of the world in which malaria is endemic, notably the Fy(a-b-) phenotype and the S-s- phenotype in Africa and the Ge- and SAO phenotypes in South East Asia. Founder effects provide a more convincing explanation for the distribution of the D- phenotype and the occurrence of hemolytic disease of the fetus and newborn in Europe and Central Asia.
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- Abstract: found
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Whole-genome sequencing for an enhanced understanding of genetic variation among South Africans
Ananyo Choudhury, Michèle Ramsay, Scott Hazelhurst … (2017)
The Southern African Human Genome Programme is a national initiative that aspires to unlock the unique genetic character of southern African populations for a better understanding of human genetic diversity. In this pilot study the Southern African Human Genome Programme characterizes the genomes of 24 individuals (8 Coloured and 16 black southeastern Bantu-speakers) using deep whole-genome sequencing. A total of ~16 million unique variants are identified. Despite the shallow time depth since divergence between the two main southeastern Bantu-speaking groups (Nguni and Sotho-Tswana), principal component analysis and structure analysis reveal significant (p < 10−6) differentiation, and FST analysis identifies regions with high divergence. The Coloured individuals show evidence of varying proportions of admixture with Khoesan, Bantu-speakers, Europeans, and populations from the Indian sub-continent. Whole-genome sequencing data reveal extensive genomic diversity, increasing our understanding of the complex and region-specific history of African populations and highlighting its potential impact on biomedical research and genetic susceptibility to disease.
Author and article information
Contributors
Genevieve Jacobs:
ORCID: https://orcid.org/0000-0003-1561-9853
Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: VisualizationRole: Writing – original draft
Karin Van den Berg: Role: SupervisionRole: Writing – review & editing
Marion Vermeulen: Role: ResourcesRole: Writing – review & editing
Ronel Swanevelder: Role: Data curationRole: Writing – review & editing
Brian Custer: Role: InvestigationRole: Writing – review & editing
Edward L. Murphy: Role: ConceptualizationRole: Project administrationRole: SupervisionRole: Writing
– review & editing
Timothy J Wade: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Title:
PLOS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
26
April
2023
Publication date Collection: 2023
Publication date PMC-release: 26
April
2023
Volume: 18
Issue: 4
Electronic Location Identifier: e0284975
Affiliations
Author notes
* E-mail:
genevieve.jacobs@
123456sanbs.org.za
Author information
Genevieve Jacobs
https://orcid.org/0000-0003-1561-9853
Article
Publisher ID: PONE-D-22-29670DOI: 10.1371/journal.pone.0284975
PMC ID: 10132593
PubMed ID: 37099490
SO-VID: d2e35e7c-74fd-4b05-9420-ead5ec83a934
Copyright © © 2023 Jacobs et al
License:
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
History
Date
received
: 27
October
2022
Date
accepted
: 12
April
2023
Page count
Figures: 1,
Tables: 1,
Pages: 8
Funding
Funded by:
funder-id http://dx.doi.org/10.13039/100016958, Office of Research Infrastructure Programs, National Institutes of Health;
Award ID: HHSN268201100009I
Funded by:
funder-id http://dx.doi.org/10.13039/100016958, Office of Research Infrastructure Programs, National Institutes of Health;
Award ID: HHSN268201100002I
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1561-9853
Genevieve Jacobs
Funded by:
funder-id http://dx.doi.org/10.13039/100016958, Office of Research Infrastructure Programs, National Institutes of Health;
Award ID: HHSN2682011-00001I
Award Recipient
:
ORCID: https://orcid.org/0000-0003-1561-9853
Genevieve Jacobs
Funded by:
funder-id http://dx.doi.org/10.13039/100000061, Fogarty International Center;
Award ID: D43-TW010345
Award Recipient
:
Edward L. Murphy
This work was supported by research contracts from the National Heart, Lung and Blood
Institute of the National Institutes of Health (NIH) for the Recipient Epidemiology
and Donor Evaluation Study-III International program: HHSN268201100009I (to UCSF and
the South African National Blood Service), HHSN268201100002I (to RTI International)
and HHSN2682011-00001I (to Vitalant Research Institute); and NIH Fogarty International
Center grant D43-TW010345 (to ELM). The funders had no role in study design, data
collection and analysis, decision to publish, or preparation of the manuscript.
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Custom metadata
Data Availability Because the analytic dataset contains sensitive information on HIV status and several
demographic and geographic variables, it is conceivably possible to identify the HIV
status of a participant of a particular sex, age, race and geographic location. Because
of this potential risk to confidentiality, requests for minimal datasets will be reviewed
by the SANBS Human Research Ethics Committee and made available consistent with regulatory
and ethical considerations in force at the time of request (contact via
https://sanbs.org.za/research).
Outbreaks COVID-19
ScienceOpen disciplines: Uncategorized
Data availability:
ScienceOpen disciplines: Uncategorized