Isavuconazole Treatment of Cerebral and Pulmonary Aspergillosis in a Pediatric Patient With Acute Lymphoblastic Leukemia: Case Report and Review of Literature.

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Abstract

Invasive aspergillosis in hematologic pediatric patients is an opportunistic infection that is difficult to treat, with a high mortality rate when localized in the central nervous system. We are describing a 3-year-old girl who was affected by acute lymphoblastic leukemia who developed cerebral and pulmonary aspergillosis during induction chemotherapy. The patient failed first-line voriconazole treatment because of being a CYP2C19 ultrarapid metabolizer and received effective isavuconazole therapy with no notable side effects.

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Journal

Journal ID (iso-abbrev): J Pediatr Hematol Oncol

Title: Journal of pediatric hematology/oncology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1536-3678

ISSN (Print): 1077-4114

Publication date (Electronic): August 2020

Volume: 42

Issue: 6

Affiliations

[1 ] Department of Pediatrics, Division of Pediatric Hematology-Oncology.

[2 ] Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari.

[3 ] IRCCS Istituto Giannina Gaslini, Children's Hospital, Genova, Italy.

Article

Publisher Item ID: 00043426-202008000-00025

DOI: 10.1097/MPH.0000000000001508

PubMed ID: 31094909

SO-VID: d13feef6-74f6-4c60-8b2e-a385ec5d5841

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