A pilot study on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving piperacillin/tazobactam.

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Abstract

In critically ill patients, multi-trauma and intensive therapy can influence the pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics with time-dependent bacterial killing. Consequently, PK/PD targets (%fT>MIC) - crucial for antimicrobial effects -may not be attained.

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Author and article information

Journal

Journal ID (iso-abbrev): Anaesthesiol Intensive Ther

Title: Anaesthesiology intensive therapy

Publisher: VM Media SP. zo.o VM Group SK

ISSN (Electronic): 1731-2531

ISSN (Print): 1642-5758

Publication date (Electronic): 2016

Volume: 48

Issue: 1

Affiliations

[1 ] Surgical Department, University Hospital, Hradec Králové, Czech Republic. kaskam@lfhk.cuni.cz.

Article

Publisher Item ID: VM/OJS/J/43067

DOI: 10.5603/AIT.a2015.0082

PubMed ID: 26588478

SO-VID: cf722cdc-e71a-4884-9106-fc86ab7fb122

History

Keywords: PK/PD target attainment,body fluid retention,piperacillin,pharmacokinetics,pharmacodynamics,personalised therapy,critically ill patients

Data availability:

Keywords: PK/PD target attainment, body fluid retention, piperacillin, pharmacokinetics, pharmacodynamics, personalised therapy, critically ill patients

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