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      Phytochemical Profile of Brown Rice and Its Nutrigenomic Implications

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          Abstract

          Whole grain foods have been promoted to be included as one of the important components of a healthy diet because of the relationship between the regular consumption of whole-grain foods and reduced risk of chronic diseases. Rice is a staple food, which has been widely consumed for centuries by many Asian countries. Studies have suggested that brown rice is associated with a wide spectrum of nutrigenomic implications such as anti-diabetic, anti-cholesterol, cardioprotective and antioxidant. This is because of the presence of various phytochemicals that are mainly located in bran layers of brown rice. Therefore, this paper is a review of publications that focuses on the bioactive compounds and nutrigenomic implications of brown rice. Although current evidence supports the fact that the consumption of brown rice is beneficial for health, these studies are heterogeneous in terms of their brown rice samples used and population groups, which cause the evaluation to be difficult. Future clinical studies should focus on the screening of individual bioactive compounds in brown rice with reference to their nutrigenomic implications.

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          Gut microbiome composition is linked to whole grain-induced immunological improvements.

          The involvement of the gut microbiota in metabolic disorders, and the ability of whole grains to affect both host metabolism and gut microbial ecology, suggest that some benefits of whole grains are mediated through their effects on the gut microbiome. Nutritional studies that assess the effect of whole grains on both the gut microbiome and human physiology are needed. We conducted a randomized cross-over trial with four-week treatments in which 28 healthy humans consumed a daily dose of 60 g of whole-grain barley (WGB), brown rice (BR), or an equal mixture of the two (BR+WGB), and characterized their impact on fecal microbial ecology and blood markers of inflammation, glucose and lipid metabolism. All treatments increased microbial diversity, the Firmicutes/Bacteroidetes ratio, and the abundance of the genus Blautia in fecal samples. The inclusion of WGB enriched the genera Roseburia, Bifidobacterium and Dialister, and the species Eubacterium rectale, Roseburia faecis and Roseburia intestinalis. Whole grains, and especially the BR+WGB treatment, reduced plasma interleukin-6 (IL-6) and peak postprandial glucose. Shifts in the abundance of Eubacterium rectale were associated with changes in the glucose and insulin postprandial response. Interestingly, subjects with greater improvements in IL-6 levels harbored significantly higher proportions of Dialister and lower abundance of Coriobacteriaceae. In conclusion, this study revealed that a short-term intake of whole grains induced compositional alterations of the gut microbiota that coincided with improvements in host physiological measures related to metabolic dysfunctions in humans.
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            Whole grain phytochemicals and health

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              Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid

              Epidemiological studies suggested that the low incidence of certain chronic diseases in rice-consuming regions of the world might be associated with the antioxidant compound contents of rice. The molecules with antioxidant activity contained in rice include phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid. This review provides information on the contents of these compounds in rice using a food composition database built from compiling data from 316 papers. The database provides access to information that would have otherwise remained hidden in the literature. For example, among the four types of rice ranked by color, black rice varieties emerged as those exhibiting the highest antioxidant activities, followed by purple, red, and brown rice varieties. Furthermore, insoluble compounds appear to constitute the major fraction of phenolic acids and proanthocyanidins in rice, but not of flavonoids and anthocyanins. It is clear that to maximize the intake of antioxidant compounds, rice should be preferentially consumed in the form of bran or as whole grain. With respect to breeding, japonica rice varieties were found to be richer in antioxidant compounds compared with indica rice varieties. Overall, rice grain fractions appear to be rich sources of antioxidant compounds. However, on a whole grain basis and with the exception of γ-oryzanol and anthocyanins, the contents of antioxidants in other cereals appear to be higher than those in rice.
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                Author and article information

                Journal
                Antioxidants (Basel)
                Antioxidants (Basel)
                antioxidants
                Antioxidants
                MDPI
                2076-3921
                23 May 2018
                June 2018
                : 7
                : 6
                : 71
                Affiliations
                [1 ]Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu 2073, Sabah, Malaysia; rkeneswary@ 123456yahoo.com
                [2 ]Department of Public Health, Xi’an Jiaotong-Liverpool University, Suzhou 215123, China; Yifan.Jin14@ 123456student.xjtlu.edu.cn
                [3 ]School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 15200, Kelantan, Malaysia
                [4 ]Department of Food Science, University of Otago, Dunedin 9016, New Zealand; zhanghongxia326@ 123456hotmail.com
                [5 ]Department of Health Promotion, Pudong Maternal and Child Health Care Institution, Shanghai 201399, China; evacaoyang@ 123456163.com
                [6 ]Department of Biochemistry, Faculty of Medicine, MAHSA University, Bandar Saujana Putra 42610, Jenjarom, Selangor, Malaysia; wang.chee@ 123456mahsa.edu.my
                [7 ]Institute of Basic Medical Sciences, Khyber Medical University, Peshawar 25100, Pakistan; shahzad.ibms@ 123456kmu.edu.pk
                [8 ]Joint Unit of Research in Nutrition and Food Science, Ibn Tofail University, Kenitra 14000, Morocco; aglagoelom@ 123456gmail.com
                [9 ]Division of Medicine, School of Life and Medical Sciences, University College London, London WC1E6BT, UK; yihe.zhang.16@ 123456ucl.ac.uk
                [10 ]Department of Clinical Nutrition, The First People’s Hospital of Wujiang District, Suzhou 215200, China; panbinyu19881102@ 123456126.com
                Author notes
                [* ]Correspondence: Zhengfeei.Ma@ 123456xjtlu.edu.cn ; Tel.: +86-512-8188-4938
                [†]

                These authors contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-7276-2229
                https://orcid.org/0000-0001-6565-1777
                Article
                antioxidants-07-00071
                10.3390/antiox7060071
                6025443
                29789516
                cf010395-0608-45d2-a2a7-d1b8cf9b78c6
                © 2018 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 21 April 2018
                : 18 May 2018
                Categories
                Review

                brown rice,nutrigenomics,phenolics,rice
                brown rice, nutrigenomics, phenolics, rice

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