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      Psychometric Evaluation of GHQ-12 as a Screening Tool for Psychological Impairment of Healthcare Workers Facing COVID-19 Pandemic

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          Abstract

          Background:

          The General Health Questionnaire (GHQ) is a widely used tool in clinical and research settings due to its brevity and easy administration. Researchers often adopt a dichotomous measurement method, considering a total score above or below a certain threshold, leading to an extreme simplification of the gathered data and, therefore, the loss of clinical details. In a multistep evaluation study aimed at assessing health care workers’ mental health during the COVID-19 pandemic, GHQ-12 proved to be the most effective tool to detect psychological distress compared to other scales. These results deepened the understanding of GHQ-12 properties through a statistical study focusing on items’ properties and characteristics.

          Methods:

          GHQ-12 responses were analyzed using Item Response Theory (IRT), a suitable method for scale assessment. Instead of considering the single overall score, in which each item accounts equally, it focuses on individual items’ characteristics. Moreover, IRT models were applied combined with the latent class (LC) analysis, aiming to determine subgroups of individuals according to their level of psychological distress.

          Results:

          GHQ-12 was administered to 990 healthcare workers, and responses were scored using the binary method (0-0-1-1). We applied the two-parameter logistic (2-PL) model, finding that the items showed different ways of responses and features. The latent class analysis classified subjects into three sub-groups according to their responses to GHQ-12 only: 47% of individuals with general well-being, 38% expressing signs of discomfort without severity, and 15% of subjects with a high level of impairment. This result almost reproduces the subjects’ classification obtained after administering the six questionnaires of the study protocol.

          Conclusions:

          Accurate statistical techniques and a deep understanding of the latent factors underlying the GHQ-12 resulted in more effective usage of such a psychometric questionnaire – i.e., a more refined gathering of data and significant time and resource efficiency. We underlined the need to maximize the extraction of data from questionnaires and the necessity of them being less lengthy and repetitive.

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          Most cited references34

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          A brief measure for assessing generalized anxiety disorder: the GAD-7.

          Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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            The PHQ-9: validity of a brief depression severity measure.

            While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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              The REDCap consortium: Building an international community of software platform partners

              The Research Electronic Data Capture (REDCap) data management platform was developed in 2004 to address an institutional need at Vanderbilt University, then shared with a limited number of adopting sites beginning in 2006. Given bi-directional benefit in early sharing experiments, we created a broader consortium sharing and support model for any academic, non-profit, or government partner wishing to adopt the software. Our sharing framework and consortium-based support model have evolved over time along with the size of the consortium (currently more than 3200 REDCap partners across 128 countries). While the "REDCap Consortium" model represents only one example of how to build and disseminate a software platform, lessons learned from our approach may assist other research institutions seeking to build and disseminate innovative technologies.
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                Author and article information

                Journal
                Med Lav
                Med Lav
                La Medicina del Lavoro
                Mattioli 1885 srl (Italy )
                0025-7818
                2532-1080
                2023
                14 February 2023
                : 114
                : 1
                : e2023009
                Affiliations
                [1 ]Occupational Health Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
                [2 ]Department of Clinical Science and Community Health, University of Milan, Milan, Italy
                [3 ]Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy
                [4 ]Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
                [5 ]Department of Neurosciences and Mental Health, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
                Author notes
                Corresponding Author: Anna Comotti, Occupational Health Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; E-mail: anna.comotti@ 123456policlinico.mi.it
                Article
                MDL-114-9
                10.23749/mdl.v114i1.13918
                9987474
                36790406
                cde7c817-cfc4-4b61-9d1f-16b7ae9daa9e
                Copyright: © 2023

                This work is licensed under a Creative Commons Attribution 4.0 International License

                History
                : 09 November 2022
                : 23 January 2023
                Categories
                Original Article

                general health questionnaires (ghq-12),occupational stress,health-care workers,item response theory

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