CDK 4/6 inhibitor palbociclib (PD0332991) in Rb+ advanced breast cancer: phase II activity, safety, and predictive biomarker assessment.

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Abstract

The G1-S checkpoint of the cell cycle is frequently dysregulated in breast cancer. Palbociclib (PD0332991) is an oral inhibitor of CDK4/6. Based upon preclinical/phase I activity, we performed a phase II, single-arm trial of palbociclib in advanced breast cancer.

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Journal

Journal ID (iso-abbrev): Clin. Cancer Res.

Title: Clinical cancer research : an official journal of the American Association for Cancer Research

ISSN: 1078-0432

ISSN (Print): 1078-0432

Publication date (Electronic): Mar 1 2015

Volume: 21

Issue: 5

Affiliations

[1 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania. Hematology/Oncology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Angela.demichele@uphs.upenn.edu.

[2 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Hematology/Oncology Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

[3 ] Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.

[4 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania.

[5 ] Department of Pathology, University of Pennsylvania, Philadelphia, Pennsylvania.

[6 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania.

[7 ] Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania. Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania.

Article

Publisher Item ID: 1078-0432.CCR-14-2258

DOI: 10.1158/1078-0432.CCR-14-2258

PubMed ID: 25501126

SO-VID: caa3d4de-7de9-45e5-9bfe-d963842b53ca

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