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      Visualisation of DCP, a nerve agent mimic, in Catfish brain by a simple chemosensor

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          Abstract

          A chemosensor, 3-aminophenol-based rhodamine conjugate (ARC) has been developed for visualisation of diethylchlorophosphate (DCP), mimic of a chemical warfare agent, in Catfish brain. The simple detection of DCP by “turn-on” fluorescence property of the chemosensor makes it unique for easy and rapid in vivo and in vitro detection of DCP with the detection limit of 5.6 nM.

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          Most cited references41

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          Fluoro- and chromogenic chemodosimeters for heavy metal ion detection in solution and biospecimens.

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            Fluorescent detection of chemical warfare agents: functional group specific ratiometric chemosensors.

            Indicators providing highly sensitive and functional group specific fluorescent response to diisopropyl fluorophosphate (DFP, a nerve gas (G-agent) simulant) are reported. Nonemissive indicator 2 reacts with DFP to give a cyclized compound 2+A- that shows a high emission due to its highly planar and rigid structure. Very weak emission was observed by the addition of HCl. Another indicator based on pyridyl naphthalene exhibits a large shift in its emission spectrum after reaction with DFP, which provides for quantitative ratiometric detection.
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              Detection of Fluorophosphonate Chemical Warfare Agents by Catalytic Hydrolysis with a Porous Silicon Interferometer

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                Author and article information

                Contributors
                prithidipa@hotmail.com
                Journal
                Sci Rep
                Sci Rep
                Scientific Reports
                Nature Publishing Group UK (London )
                2045-2322
                21 February 2018
                21 February 2018
                2018
                : 8
                : 3402
                Affiliations
                [1 ]ISNI 0000 0001 2259 7889, GRID grid.440987.6, Department of Chemistry, , Visva-Bharati University, ; Santiniketan, 731235 India
                [2 ]ISNI 0000 0001 0664 9773, GRID grid.59056.3f, Department of Microbiology, , University of Calcutta, ; Kolkata, 700019 India
                [3 ]ISNI 0000 0001 2259 7889, GRID grid.440987.6, Department of Zoology, , Visva-Bharati University, ; Santiniketan, 731235 India
                Author information
                http://orcid.org/0000-0003-4638-5826
                http://orcid.org/0000-0002-7752-0982
                http://orcid.org/0000-0001-8493-7068
                Article
                21780
                10.1038/s41598-018-21780-5
                5821826
                29467435
                c8d4dea2-8394-497e-a8c8-ce70ed3c4186
                © The Author(s) 2018

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 25 October 2017
                : 9 February 2018
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