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      Use of Ecological Momentary Assessment Through a Passive Smartphone-Based App (eB2) by Patients With Schizophrenia: Acceptability Study

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      , MD, PhD 1 , 2 , 3 , 4 , , , MD, PhD 1 , 2 , , MD, PhD 1 , 5 , , MD 1 , 2 , , MD 1 , 2 , , MD 1 , , MD 1 , , MD, PhD 1 , , MD, PhD 1 , , PhD 3 , 6 , 7 , 8 , , MD 9 , , MD, PhD 1 , 2 , 3 , 5 , 10 , 11 , 12 , 13
      (Reviewer), (Reviewer), (Reviewer)
      Journal of Medical Internet Research
      JMIR Publications
      ecological momentary assessment, acceptability, schizophrenia spectrum disorders, eB2, digital tools, mental health, schizophrenia, real-time data, patients, digital health, internet, mobile apps

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          Abstract

          Background

          Ecological momentary assessment (EMA) tools appear to be useful interventions for collecting real-time data on patients’ behavior and functioning. However, concerns have been voiced regarding the acceptability of EMA among patients with schizophrenia and the factors influencing EMA acceptability.

          Objective

          The aim of this study was to investigate the acceptability of a passive smartphone-based EMA app, evidence-based behavior (eB2), among patients with schizophrenia spectrum disorders and the putative variables underlying their acceptance.

          Methods

          The participants in this study were from an ongoing randomized controlled trial (RCT) of metacognitive training, consisting of outpatients with schizophrenia spectrum disorders (F20-29 of 10th revision of the International Statistical Classification of Diseases and Related Health Problems), aged 18-64 years, none of whom received any financial compensation. Those who consented to installation of the eB2 app (users) were compared with those who did not (nonusers) in sociodemographic, clinical, premorbid adjustment, neurocognitive, psychopathological, insight, and metacognitive variables. A multivariable binary logistic regression tested the influence of the above (independent) variables on “being user versus nonuser” (acceptability), which was the main outcome measure.

          Results

          Out of the 77 RCT participants, 24 (31%) consented to installing eB2, which remained installed till the end of the study (median follow-up 14.50 weeks) in 14 participants (70%). Users were younger and had a higher education level, better premorbid adjustment, better executive function (according to the Trail Making Test), and higher cognitive insight levels (measured with the Beck Cognitive Insight Scale) than nonusers (univariate analyses) although only age (OR 0.93, 95% CI 0.86-0.99; P=.048) and early adolescence premorbid adjustment (OR 0.75, 95% CI 0.61-0.93; P=.01) survived the multivariable regression model, thus predicting eB2 acceptability.

          Conclusions

          Acceptability of a passive smartphone-based EMA app among participants with schizophrenia spectrum disorders in this RCT where no participant received financial compensation was, as expected, relatively low, and linked with being young and good premorbid adjustment. Further research should examine how to increase EMA acceptability in patients with schizophrenia spectrum disorders, in particular, older participants and those with poor premorbid adjustment.

          Trial Registration

          ClinicalTrials.gov NCT04104347; https://clinicaltrials.gov/ct2/show/NCT04104347

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          Most cited references64

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          Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science

          Summary The coronavirus disease 2019 (COVID-19) pandemic is having a profound effect on all aspects of society, including mental health and physical health. We explore the psychological, social, and neuroscientific effects of COVID-19 and set out the immediate priorities and longer-term strategies for mental health science research. These priorities were informed by surveys of the public and an expert panel convened by the UK Academy of Medical Sciences and the mental health research charity, MQ: Transforming Mental Health, in the first weeks of the pandemic in the UK in March, 2020. We urge UK research funding agencies to work with researchers, people with lived experience, and others to establish a high level coordination group to ensure that these research priorities are addressed, and to allow new ones to be identified over time. The need to maintain high-quality research standards is imperative. International collaboration and a global perspective will be beneficial. An immediate priority is collecting high-quality data on the mental health effects of the COVID-19 pandemic across the whole population and vulnerable groups, and on brain function, cognition, and mental health of patients with COVID-19. There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19. Discovery, evaluation, and refinement of mechanistically driven interventions to address the psychological, social, and neuroscientific aspects of the pandemic are required. Rising to this challenge will require integration across disciplines and sectors, and should be done together with people with lived experience. New funding will be required to meet these priorities, and it can be efficiently leveraged by the UK's world-leading infrastructure. This Position Paper provides a strategy that may be both adapted for, and integrated with, research efforts in other countries.
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            The Positive and Negative Syndrome Scale (PANSS) for Schizophrenia

            The variable results of positive-negative research with schizophrenics underscore the importance of well-characterized, standardized measurement techniques. We report on the development and initial standardization of the Positive and Negative Syndrome Scale (PANSS) for typological and dimensional assessment. Based on two established psychiatric rating systems, the 30-item PANSS was conceived as an operationalized, drug-sensitive instrument that provides balanced representation of positive and negative symptoms and gauges their relationship to one another and to global psychopathology. It thus constitutes four scales measuring positive and negative syndromes, their differential, and general severity of illness. Study of 101 schizophrenics found the four scales to be normally distributed and supported their reliability and stability. Positive and negative scores were inversely correlated once their common association with general psychopathology was extracted, suggesting that they represent mutually exclusive constructs. Review of five studies involving the PANSS provided evidence of its criterion-related validity with antecedent, genealogical, and concurrent measures, its predictive validity, its drug sensitivity, and its utility for both typological and dimensional assessment.
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              VALIDITY OF THE TRAIL MAKING TEST AS AN INDICATOR OF ORGANIC BRAIN DAMAGE

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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                J Med Internet Res
                JMIR
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                1439-4456
                1438-8871
                July 2021
                26 July 2021
                : 23
                : 7
                : e26548
                Affiliations
                [1 ] Departamento de Psiquiatria, IIS-Fundación Jiménez Díaz Madrid Spain
                [2 ] Departamento de Psiquiatria, Universidad Autónoma de Madrid Madrid Spain
                [3 ] Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid Spain
                [4 ] Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense Madrid Spain
                [5 ] Departamento de Psiquiatria, Hospital Universitario Rey Juan Carlos Móstoles, Madrid Spain
                [6 ] Departamento de Teoría de Señal y de la Comunicación, Universidad Carlos III Madrid Spain
                [7 ] Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM) Madrid Spain
                [8 ] Evidence-Based Behavior Leganés, Madrid Spain
                [9 ] Institute of Mental Health, University College London London United Kingdom
                [10 ] Universidad Católica del Maule Talca Chile
                [11 ] Departamento de Psiquiatría, Hospital Universitario Central de Villalba Madrid Spain
                [12 ] Departamento de Psiquiatría, Hospital Universitario Infanta Elena Valdemoro, Madrid Spain
                [13 ] Université de Nîmes Nimes France
                Author notes
                Corresponding Author: Javier-David Lopez-Morinigo javierd.lopez@ 123456uam.es
                Author information
                https://orcid.org/0000-0002-4264-2664
                https://orcid.org/0000-0002-2497-6353
                https://orcid.org/0000-0003-2019-9099
                https://orcid.org/0000-0002-8346-3259
                https://orcid.org/0000-0002-2113-752X
                https://orcid.org/0000-0003-2579-7370
                https://orcid.org/0000-0002-5495-3144
                https://orcid.org/0000-0001-6847-1229
                https://orcid.org/0000-0003-0855-5812
                https://orcid.org/0000-0001-6540-7109
                https://orcid.org/0000-0003-0967-774X
                https://orcid.org/0000-0002-6963-6555
                Article
                v23i7e26548
                10.2196/26548
                8367186
                34309576
                c58ce6f1-d90a-4ddf-9831-f70b0e825be6
                ©Javier-David Lopez-Morinigo, María Luisa Barrigón, Alejandro Porras-Segovia, Verónica González Ruiz-Ruano, Adela Sánchez Escribano Martínez, Paula Jhoana Escobedo-Aedo, Sergio Sánchez Alonso, Laura Mata Iturralde, Laura Muñoz Lorenzo, Antonio Artés-Rodríguez, Anthony S David, Enrique Baca-García. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 26.07.2021.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

                History
                : 16 December 2020
                : 14 January 2021
                : 10 February 2021
                : 13 May 2021
                Categories
                Original Paper
                Original Paper

                Medicine
                ecological momentary assessment,acceptability,schizophrenia spectrum disorders,eb2,digital tools,mental health,schizophrenia,real-time data,patients,digital health,internet,mobile apps

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