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      Regulations and Ethical Considerations in Animal Experiments: International Laws and Islamic Perspectives

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          Abstract

          Growing usage of animals in the research projects has drawn more attention to their welfare and ethics surrounding this practice. Dissemination of information about the existing ethical consideration and alternatives in animal experiments has two important functions; first, it increases the researcher's awareness of the possible methods of using animals in the experiment, and second, to ensure that potential users are aware of the established alternatives. For example, legislations enacted in many countries during the 1980s state that laboratory animal applications should be reduced, refined and replaced wherever possible according to principles of the 3Rs. Thus, scientists around the world tried to apply the 3Rs in their biomedical researches regarding welfare of the laboratory animals. However, the Qur'an, the holy book of Muslims, and also Hadiths contain the obligatory ways to keep and treat animals since their revelations. According to Islamic viewpoint, animals represent Allah's ability and wisdom, and humans must pay attention to their health and living conditions. Several Islamic manuscripts state that animals have their own position in the creation hierarchy and humans are responsible for supplying minimal facilities and their welfare. This paper has tried to review ethical consideration in animal experiments and regarding Islamic resources in this case to encourage providing comprehensive ethical regulations in animal experiments which its establishment could be beneficial for animal ethics committees or research institutes.

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          Most cited references22

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          2000 Report of the AVMA Panel on Euthanasia.

          (2001)
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            Guide for the Care and Use of Laboratory Animals

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              Recognizing and assessing pain, suffering and distress in laboratory animals: a survey of current practice in the UK with recommendations.

              A survey was undertaken to evaluate how animal pain, suffering and distress are recognized and assessed in UK scientific procedure establishments designated under the Animals (Scientific Procedures) Act 1986. A total of 28 institutions were visited between June 1999 and April 2001, within which 137 people were interviewed including scientists, veterinarians and animal technicians. All 28 establishments use clinical observation sheets to assist the recognition of adverse effects, nine use score sheets and seven use computerized data management systems. Clinical signs used as indicators of potential pain, suffering or distress are largely subjective. The survey also addressed protocols and methods for avoiding and alleviating adverse effects, record keeping, review of policies and protocols and issues relating to team work and training. Respondents use a range of techniques for reducing suffering including analgesia, humane endpoints, ensuring competence and refining husbandry. All establishments review projects regularly but few have the time or resources formally to review adverse effects noted in practice and to compare observations with predictions made in licence applications. Training is very consistent between different establishments and most aim to achieve a 'team approach' for monitoring and assessing animals. Results are summarized in the present, abridged paper and set out in full in a report that can be downloaded at http://www.lal.org.uk/pain/(Hawkins 2002). The present paper and the full report, including its recommendations, are intended to provide a source of information, discussion topics and ideas for all establishments that need to monitor animal well-being.
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                Author and article information

                Journal
                Avicenna J Med Biotechnol
                Avicenna J Med Biotechnol
                AJMB
                Avicenna Journal of Medical Biotechnology
                Avicenna Research Institute
                2008-2835
                2008-4625
                Jul-Sep 2012
                : 4
                : 3
                : 114-120
                Affiliations
                [1 ]Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
                [2 ]Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
                [3 ]Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
                []These authors equally contribute to this work
                Author notes
                [* ] Corresponding author: Mohammad Mehdi Akhondi, Ph.D., Monoclonal Antibody Research Center, Avicenna Research institute, ACECR, Tehran, Iran. Tel: +98 22432020. Fax: +98 21 22432021. E-mail: akhondi@ 123456avicenna.ac.ir
                Article
                AJMB-4-114
                3558218
                23407588
                c5088831-3d48-4e34-8626-53bfd336ec27
                Copyright © 2012 Avicenna Research Institute

                This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.

                History
                : 20 February 2012
                : 14 May 2012
                Categories
                Review Article

                Biotechnology
                welfare,animals,research,ethics
                Biotechnology
                welfare, animals, research, ethics

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