According to Greene et al.'s dual-process theory, the differential involvement of emotional processes would explain the different patterns of moral judgments people typically produce when faced with Trolley- and Footbridge-type dilemmas. As a relevant factor, dispositional empathy is known to motivate prosocial behaviors, thus playing a central role in moral judgment and behavior. The present study was aimed at investigating how behavioral and neural correlates of moral decision-making are modulated by the cognitive and affective dimensions of empathy. Thirty-seven participants were presented with 30 Footbridge-type and 30 Trolley-type dilemmas. Participants were required to decide between two options: letting some people die (non-utilitarian) vs. killing one person to save more people (utilitarian). Event-related potentials (ERPs) were recorded stimulus-locked to a "decision slide". Response choices and ratings of valence and arousal were also collected. Trait empathy was measured through the Interpersonal Reactivity Index (IRI), assessing both the cognitive and affective dimensions. Scores on the Empathic Concern affective subscale of the IRI positively predicted unpleasantness experienced during decision-making for all dilemmas. On the other hand, for Footbridge-type dilemmas only, scores on the Personal Distress affective subscale predicted negatively the mean percentages of utilitarian choices and positively the mean amplitudes of the P260, an ERP component reflecting an immediate emotional reaction during decision-making. It is concluded that "self-oriented" feelings of anxiety and unease, rather than "other-oriented" feelings of concern, affect behavioral choices and emotion-related cortical activity in Footbridge-type moral dilemmas. Copyright © 2014 Elsevier Inc. All rights reserved.