The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma patients.

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Abstract

The Standardized Uptake Value (SUV) in single lesions on 18F-FDG PET/CT scans and serum S-100B concentrations are inversely associated with disease-free survival in stage IV melanoma. The aim of this study was to assess the association between biomarkers (S-100B, LDH) and the PET-derived metrics SUVmean/max, metabolic active tumor volume (MATV), and total lesion glycolysis (TLG) in stage IV melanoma in order to understand what these biomarkers reflect and their possible utility for follow-up.

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Journal

Journal ID (iso-abbrev): Eur J Surg Oncol

Title: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

Publisher: Elsevier BV

ISSN (Electronic): 1532-2157

ISSN (Print): 0748-7983

Publication date (Electronic): November 2020

Volume: 46

Issue: 11

Affiliations

[1 ] Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: e.a.deckers@umcg.nl.

[2 ] Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: s.kruijff@umcg.nl.

[3 ] Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

[4 ] Department of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

[5 ] Melanoma Institute Australia, Faculty of Medicine and Health, The University of Sydney, Department of Melanoma and Surgical Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia.

[6 ] Department of Surgery, Isala Clinics, Zwolle, the Netherlands.

Article

Publisher Item ID: S0748-7983(20)30637-5

DOI: 10.1016/j.ejso.2020.07.011

PubMed ID: 32819759

SO-VID: c34f3fcb-7db4-48d5-9ccf-66b3d50c7a1a

History

Keywords: S-100B,Melanoma,LDH,Biomarkers,Staging,PET

Data availability:

Keywords: S-100B, Melanoma, LDH, Biomarkers, Staging, PET

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