Ulcerative Colitis Is Under Dual (Mitochondrial and Nuclear) Genetic Control.

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Abstract

Cellular oxidative stress and genetic susceptibility have been implicated in the multifactorial etiology of ulcerative colitis (UC). The nuclear genome association with UC has been intensely investigated, but the role of the mitochondrial DNA (mtDNA) has received far less attention and may account for part of the missing heritability. This study is a comprehensive analysis of the mtDNA contribution to UC susceptibility.

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Journal

Journal ID (iso-abbrev): Inflamm. Bowel Dis.

Title: Inflammatory bowel diseases

ISSN (Electronic): 1536-4844

ISSN (Print): 1078-0998

Publication date (Electronic): Apr 2016

Volume: 22

Issue: 4

Affiliations

[1 ] *Unidade de Ciências Médicas, Centro de Competências das Ciências da Vida, Universidade da Madeira, Funchal, Portugal; †Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; ‡Instituto Gulbenkian de Ciência, Oeiras, Portugal; and §Centre for Biomedical Research (CBMR), Universidade do Algarve, Faro, Portugal.

Article

DOI: 10.1097/MIB.0000000000000694

PubMed ID: 26926037

SO-VID: bb51dd92-c321-4000-ab10-9b9d7b7b87b7

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