All around suboptimal health — a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine

Author(s): Wei Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ ^, , Yuxiang Yan ² ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Zheng Guo ¹ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Haifeng Hou ¹ ^, ³ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Monique Garcia ¹ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Xuerui Tan ⁴ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Enoch Odame Anto ¹ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ ^, ¹⁰ , Gehendra Mahara ⁴ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Yulu Zheng ¹ ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Bo Li ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ ^, ¹¹ , Timothy Kang ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ ^, ¹² , Zhaohua Zhong ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ ^, ¹³ , Youxin Wang ¹ ^, ² ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ¹⁰ , Xiuhua Guo ² ^, ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ , Olga Golubnitschaja ⁵ ^, ⁶ ^, ⁷ ^, ⁸ ^, ⁹ ^, ¹⁴ ^, , On Behalf of Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine

Publication date (Electronic): 13 September 2021

Journal: The EPMA Journal

Publisher: Springer International Publishing

Keywords: Predictive preventive personalised medicine (PPPM/3PM), Suboptimal health status (SHS), Traditional medicine, Body mass index (BMI), Multi-level diagnostics, Omics, Glycan, Liquid biopsy, Modifiable preventable risks, Risk assessment, Communicable, Non-communicable diseases, Adolescence, Stress overload, Cardiovascular disease, Cancers, Neurologic diseases, Mood disorders, Microbiome, Periodontal health, Natural substances, Lifestyle, Dietary habits, Behavioural patterns, Sleep medicine, Individualised patient profile, Artificial intelligence (AI), Multi-parametric analysis, Big data management, Medical ethics, Health economy, Health policy, Epidemics, Pandemics, COVID-19

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Abstract

First two decades of the twenty-first century are characterised by epidemics of non-communicable diseases such as many hundreds of millions of patients diagnosed with cardiovascular diseases and the type 2 diabetes mellitus, breast, lung, liver and prostate malignancies, neurological, sleep, mood and eye disorders, amongst others. Consequent socio-economic burden is tremendous. Unprecedented decrease in age of maladaptive individuals has been reported. The absolute majority of expanding non-communicable disorders carry a chronic character, over a couple of years progressing from reversible suboptimal health conditions to irreversible severe pathologies and cascading collateral complications. The time-frame between onset of SHS and clinical manifestation of associated disorders is the operational area for an application of reliable risk assessment tools and predictive diagnostics followed by the cost-effective targeted prevention and treatments tailored to the person.

This article demonstrates advanced strategies in bio/medical sciences and healthcare focused on suboptimal health conditions in the frame-work of Predictive, Preventive and Personalised Medicine (3PM/PPPM). Potential benefits in healthcare systems and for society at large include but are not restricted to an improved life-quality of major populations and socio-economical groups, advanced professionalism of healthcare-givers and sustainable healthcare economy. Amongst others, following medical areas are proposed to strongly benefit from PPPM strategies applied to the identification and treatment of suboptimal health conditions:

Stress overload associated pathologies
Male and female health
Planned pregnancies
Periodontal health
Eye disorders
Inflammatory disorders, wound healing and pain management with associated complications
Metabolic disorders and suboptimal body weight
Cardiovascular pathologies
Cancers
Stroke, particularly of unknown aetiology and in young individuals
Sleep medicine
Sports medicine
Improved individual outcomes under pandemic conditions such as COVID-19.

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Author and article information

Contributors

Wei Wang: wei.wang@ecu.edu.au

Olga Golubnitschaja: Olga.Golubnitschaja@ukbonn.de

Journal

Journal ID (nlm-ta): EPMA J

Journal ID (iso-abbrev): EPMA J

Title: The EPMA Journal

Publisher: Springer International Publishing (Cham )

ISSN (Print): 1878-5077

ISSN (Electronic): 1878-5085

Publication date (Electronic): 13 September 2021

Publication date PMC-release: 13 September 2021

Pages: 1-31

Affiliations

[1 ]GRID grid.1038.a, ISNI 0000 0004 0389 4302, Centre for Precision Health, , Edith Cowan University, ; Perth, Australia

[2 ]GRID grid.24696.3f, ISNI 0000 0004 0369 153X, Beijing Key Laboratory of Clinical Epidemiology, , Capital Medical University, ; Beijing, China

[3 ]School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai’an, China

[4 ]GRID grid.411679.c, ISNI 0000 0004 0605 3373, First Affiliated Hospital, , Shantou University Medical College, ; Shantou, China

[5 ]Suboptimal Health Study Consortium, Kumasi, Ghana

[6 ]Suboptimal Health Study Consortium, Perth, Australia

[7 ]Suboptimal Health Study Consortium, Beijing, China

[8 ]Suboptimal Health Study Consortium, Bonn, Germany

[9 ]European Association for Predictive, Preventive and Personalised, Medicine, Brussels, Belgium

[10 ]GRID grid.9829.a, ISNI 0000000109466120, Department of Medical Diagnostics, , College of Health Science, Kwame Nkrumah University of Science and Technology, ; Kumasi, Ghana

[11 ]GRID grid.256922.8, ISNI 0000 0000 9139 560X, School of Nursing and Health, , Henan University, ; Kaifeng, China

[12 ]Institute of Chinese Acuology, Perth, Australia

[13 ]GRID grid.410736.7, ISNI 0000 0001 2204 9268, School of Basic Medicine, Harbin Medical University, ; Harbin, China

[14 ]GRID grid.10388.32, ISNI 0000 0001 2240 3300, Predictive, Preventive and Personalised (3P) Medicine, Department of Radiation Oncology, , University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, ; Bonn, Germany

Article

Publisher ID: 253

DOI: 10.1007/s13167-021-00253-2

PMC ID: 8435766

PubMed ID: 34539937

SO-VID: b9cc5889-6879-4a47-9f38-bf4bc6e084ee

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 20 July 2021

Date accepted : 25 August 2021

Funding

Funded by: Rheinische Friedrich-Wilhelms-Universität Bonn (1040)

Open Access :

Open Access funding enabled and organized by Projekt DEAL.

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All around suboptimal health — a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine

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Most cited references 148

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2019

Construct validity in psychological tests.

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