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      Effect of disinfectants on the tear strength of addition silicone impression material – An in vitro study

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          Abstract

          Addition silicone is a newer type of silicone impression material which has high dimensional stability, accuracy, and flexibility. They are mostly used for fixed restorations such as crowns and bridges. They have high tear strength; however, this strength may be altered upon disinfection. Disinfection of addition silicone prior use is important to reduce the microbial load. The aim of this study is to check whether there is any change in tear strength of addition silicone on disinfection with two commercially available disinfectants. Zhermack Elite HD + Putty material was tested in this study. Base and catalyst material was mixed and the material was cut into strips of dimension 70 mm × 10 mm × 2 mm. Five strips were immersed in sterillium and five strips were immersed in glutaraldehyde solution. These strips were then tested for their tear strength using Instron E3000 Universal Testing Machine. The values obtained were recorded in SPSS software version 22 (IBM SPSS Statistics for Windows, Version 23.0. Armonk, NY: IBM Corp.) for analysis and the P was obtained. The mean tear strength of Group 1, addition silicone immersed in sterillium disinfecting solution was found to be 7.148 ± 2.654 kN/m. The mean tear strength of Group 2, addition silicone immersed in glutaraldehyde disinfectant solution was found to be 7.326 ± 4.062 kN/m. An unpaired Student's t-test was done and P was found to be 0.235. The tear strength values between the groups was statistically not significant. Hence the tear strength of addition silicone was found to be greater in the glutaraldehyde disinfectant solution group.

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          The m6A readers YTHDF1 and YTHDF3 aberrations associated with metastasis and predict poor prognosis in breast cancer patients

          N6-Methyladenosine (m6A) is the most common RNA modification in eukaryotic mRNAs and growing evidence suggests the crucial roles of m6A and its regulators in human tumorigenesis. Recent studies have shown that the m6A regulators promote tumorigenesis of various types of cancer. However, the underlying molecular mechanisms of m6A regulators in breast cancer remain largely unknown. We therefore assessed the genetic alterations, expression and prognostic role of m6A regulators in breast cancer using openly available data from The Cancer Genome Atlas (TCGA). Analysis of TCGA data revealed that m6A regulators including KIAA1429 , YTHDF1 , and YTHDF3 were upregulated in breast cancer tissues, and the expression level significantly correlated with intrinsic subclasses and nodal metastasis. Importantly, we found for the first time that YTHDF1 and YTHDF3 were frequently amplified which contribute to the overexpression of YTHDF1 and YTHDF3 transcripts, thereby promoting breast cancer progression. Moreover, overexpression of YTHDF1 and YTHDF3 were associated with poor prognosis of breast cancer patients. Therefore, YTHDF1 and YTHDF3 serve a crucial role in the pathogenesis of breast cancer, which are potentially useful for prognosis stratification and therapeutic target for breast cancer.
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            Phyto-assisted synthesis of zinc oxide nanoparticles using Cassia alata and its antibacterial activity against Escherichia coli

            Zinc oxide, an established inorganic metal oxide in nanoparticles form exhibits tremendous anti-bacterial activity. The present study focuses on determining the anti-bacterial activity of green synthesized zinc oxide nanoparticles (ZnO NPs). Results clearly validate the effective synthesis of spherical shaped nanoparticles with average size range of 60–80 nm. SEM and EDAX data buttresses the results obtained by XRD pattern in terms of size and purity. ZnO NPs exhibited dose-dependent anti-bacterial activity against Escherichia coli (E. coli) and the IC50 value was calculated to be around 20 μg/mL. Growth kinetics study was conducted in the presence of nanoparticles which demonstrated the bacteriostatic effect of ZnO NPs. The study recommends the potential use of ZnO NPs in industries like food, pharmaceutical, agriculture, cosmetic industries for its anti-bacterial activity.
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              Recent advancement in the natural fiber polymer composites: A comprehensive review

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                Author and article information

                Journal
                J Adv Pharm Technol Res
                J Adv Pharm Technol Res
                JAPTR
                Journal of Advanced Pharmaceutical Technology & Research
                Wolters Kluwer - Medknow (India )
                2231-4040
                0976-2094
                December 2022
                30 December 2022
                : 13
                : Suppl 2
                : S458-S461
                Affiliations
                [1]Undergraduate Student, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
                [1 ]White Lab-Material Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India
                Author notes
                Address for correspondence: Dr. S. Balaji Ganesh, White Lab-Material Research Centre, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai - 600 077, Tamil Nadu, India. E-mail: balajiganeshs.sdc@ 123456saveetha.com
                Article
                JAPTR-13-458
                10.4103/japtr.japtr_270_22
                9926602
                b8a33553-f1f1-4cae-be3b-ed38f9c25599
                Copyright: © 2022 Journal of Advanced Pharmaceutical Technology & Research

                This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.

                History
                : 28 April 2022
                : 12 July 2022
                Categories
                Original Article

                Pharmacology & Pharmaceutical medicine
                addition silicone,disinfection,glutaraldehyde,innovative technique,sterillium,tear strength

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