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      Using a latent Hawkes process for epidemiological modelling

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          Abstract

          Understanding the spread of COVID-19 has been the subject of numerous studies, highlighting the significance of reliable epidemic models. Here, we introduce a novel epidemic model using a latent Hawkes process with temporal covariates for modelling the infections. Unlike other models, we model the reported cases via a probability distribution driven by the underlying Hawkes process. Modelling the infections via a Hawkes process allows us to estimate by whom an infected individual was infected. We propose a Kernel Density Particle Filter (KDPF) for inference of both latent cases and reproduction number and for predicting the new cases in the near future. The computational effort is proportional to the number of infections making it possible to use particle filter type algorithms, such as the KDPF. We demonstrate the performance of the proposed algorithm on synthetic data sets and COVID-19 reported cases in various local authorities in the UK, and benchmark our model to alternative approaches.

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          Most cited references26

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          Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe

          Following the detection of the new coronavirus1 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its spread outside of China, Europe has experienced large epidemics of coronavirus disease 2019 (COVID-19). In response, many European countries have implemented non-pharmaceutical interventions, such as the closure of schools and national lockdowns. Here we study the effect of major interventions across 11 European countries for the period from the start of the COVID-19 epidemics in February 2020 until 4 May 2020, when lockdowns started to be lifted. Our model calculates backwards from observed deaths to estimate transmission that occurred several weeks previously, allowing for the time lag between infection and death. We use partial pooling of information between countries, with both individual and shared effects on the time-varying reproduction number (Rt). Pooling allows for more information to be used, helps to overcome idiosyncrasies in the data and enables more-timely estimates. Our model relies on fixed estimates of some epidemiological parameters (such as the infection fatality rate), does not include importation or subnational variation and assumes that changes in Rt are an immediate response to interventions rather than gradual changes in behaviour. Amidst the ongoing pandemic, we rely on death data that are incomplete, show systematic biases in reporting and are subject to future consolidation. We estimate that-for all of the countries we consider here-current interventions have been sufficient to drive Rt below 1 (probability Rt < 1.0 is greater than 99%) and achieve control of the epidemic. We estimate that across all 11 countries combined, between 12 and 15 million individuals were infected with SARS-CoV-2 up to 4 May 2020, representing between 3.2% and 4.0% of the population. Our results show that major non-pharmaceutical interventions-and lockdowns in particular-have had a large effect on reducing transmission. Continued intervention should be considered to keep transmission of SARS-CoV-2 under control.
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            A New Framework and Software to Estimate Time-Varying Reproduction Numbers During Epidemics

            Abstract The quantification of transmissibility during epidemics is essential to designing and adjusting public health responses. Transmissibility can be measured by the reproduction number R, the average number of secondary cases caused by an infected individual. Several methods have been proposed to estimate R over the course of an epidemic; however, they are usually difficult to implement for people without a strong background in statistical modeling. Here, we present a ready-to-use tool for estimating R from incidence time series, which is implemented in popular software including Microsoft Excel (Microsoft Corporation, Redmond, Washington). This tool produces novel, statistically robust analytical estimates of R and incorporates uncertainty in the distribution of the serial interval (the time between the onset of symptoms in a primary case and the onset of symptoms in secondary cases). We applied the method to 5 historical outbreaks; the resulting estimates of R are consistent with those presented in the literature. This tool should help epidemiologists quantify temporal changes in the transmission intensity of future epidemics by using surveillance data.
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              Particle Markov chain Monte Carlo methods

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole: SoftwareRole: ValidationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: ConceptualizationRole: SupervisionRole: ValidationRole: Writing – review & editing
                Role: SupervisionRole: ValidationRole: Writing – review & editing
                Role: Editor
                Journal
                PLoS One
                PLoS One
                plos
                PLOS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                2023
                1 March 2023
                : 18
                : 3
                : e0281370
                Affiliations
                [001] Department of Mathematics, Imperial College London, London, United Kingdom
                Adana Alparslan Turkes Science and Technology University: Adana Alparslan Turkes Bilim ve Teknoloji Universitesi, TURKEY
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-6777-0451
                https://orcid.org/0000-0001-9033-7472
                Article
                PONE-D-22-21752
                10.1371/journal.pone.0281370
                9977047
                36857340
                b72cd0d0-3e07-48ba-b997-026ef0ea92f6
                © 2023 Lamprinakou et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 3 August 2022
                : 23 January 2023
                Page count
                Figures: 12, Tables: 5, Pages: 27
                Funding
                The author(s) received no specific funding for this work.
                Categories
                Research Article
                Physical Sciences
                Mathematics
                Applied Mathematics
                Algorithms
                Research and Analysis Methods
                Simulation and Modeling
                Algorithms
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Viral Diseases
                Covid 19
                Medicine and Health Sciences
                Medical Conditions
                Infectious Diseases
                Infectious Disease Modeling
                Biology and Life Sciences
                Computational Biology
                Population Modeling
                Infectious Disease Modeling
                Biology and Life Sciences
                Population Biology
                Population Modeling
                Infectious Disease Modeling
                Medicine and Health Sciences
                Urology
                Genitourinary Infections
                Physical Sciences
                Mathematics
                Probability Theory
                Probability Distribution
                Medicine and Health Sciences
                Epidemiology
                Pandemics
                Physical Sciences
                Mathematics
                Operator Theory
                Kernel Functions
                Research and Analysis Methods
                Mathematical and Statistical Techniques
                Statistical Methods
                Forecasting
                Physical Sciences
                Mathematics
                Statistics
                Statistical Methods
                Forecasting
                Custom metadata
                All data can be found on the UK covid website: https://coronavirus.data.gov.uk/details/download.

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