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      Predicting Real-World Effectiveness of Cancer Therapies Using Overall Survival and Progression-Free Survival from Clinical Trials: Empirical Evidence for the ASCO Value Framework.

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          Abstract

          To measure the relationship between randomized controlled trial (RCT) efficacy and real-world effectiveness for oncology treatments as well as how this relationship varies depending on an RCT's use of surrogate versus overall survival (OS) endpoints.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Value Health
          Title: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research
          Publisher: Elsevier BV
          ISSN (Electronic): 1524-4733
          ISSN (Print): 1098-3015
          Publication date (Electronic): July 18 2017
          Volume: 20
          Issue: 7
          Affiliations
          [1 ] Leonard D. Schaeffer Center for Health Policy and Economics, University of Southern California, Los Angeles, CA, USA. Electronic address: dlakdawa@usc.edu.
          [2 ] Precision Health Economics, Los Angeles, CA, USA.
          [3 ] Novartis Pharmaceuticals, East Hanover, NJ, USA.
          [4 ] University of California, Los Angeles, CA, USA.
          [5 ] Cedars-Sinai Medical Center, Los Angeles, CA, USA.
          Article
          Publisher Item ID: S1098-3015(17)30203-6
          DOI: 10.1016/j.jval.2017.04.003
          PubMed ID: 28712615
          SO-VID: b5fa2b07-a896-48b7-ac12-2f2cfc6cdb08
          History

          Keywords: treatment comparisons,mortality,methodology,cancer
          Data availability:
          Keywords: treatment comparisons, mortality, methodology, cancer

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