Zhen-Yong Keck: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: SupervisionRole: Writing – original draftRole:
Writing – review & editing
Brian G. Pierce: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Patrick Lau: Role: Investigation
Janine Lu: Role: Investigation
Yong Wang: Role: Investigation
Alexander Underwood:
ORCID: http://orcid.org/0000-0001-7971-6906
Role: Data curation
Rowena A. Bull:
ORCID: http://orcid.org/0000-0002-9844-3744
Role: InvestigationRole: Resources
Jannick Prentoe:
ORCID: http://orcid.org/0000-0003-2203-9478
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Rodrigo Velázquez-Moctezuma:
ORCID: http://orcid.org/0000-0001-9865-152X
Role: Data curation
Melanie R. Walker: Role: Investigation
Fabio Luciani: Role: Investigation
Johnathan D. Guest: Role: Investigation
Catherine Fauvelle:
ORCID: http://orcid.org/0000-0003-4364-5127
Role: Investigation
Thomas F. Baumert: Role: Data curationRole: Formal analysisRole: Funding acquisitionRole: ResourcesRole:
Supervision
Jens Bukh:
ORCID: http://orcid.org/0000-0002-7815-4806
Role: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: Writing – original draftRole: Writing – review & editing
Andrew R. Lloyd: Role: Funding acquisitionRole: Resources
Steven K. H. Foung:
ORCID: http://orcid.org/0000-0001-7149-6160
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
Writing – original draftRole: Writing – review & editing
Félix A. Rey: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
17
May
2019
Publication date Collection:
May
2019
Volume: 15
Issue: 5
Electronic Location Identifier: e1007772
Affiliations
[1
]
Department of Pathology, Stanford University School of Medicine, Stanford, California,
United States of America
[2
]
University of Maryland Institute for Bioscience and Biotechnology Research, Rockville,
Maryland, United States of America
[3
]
Department of Cell Biology and Molecular Genetics, University of Maryland, College
Park, Maryland, United States of America
[4
]
Viral Immunology Systems Program, The Kirby Institute and School of Medical Sciences,
University of New South Wales, Sydney, NSW, Australia
[5
]
Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases, Hvidovre
Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical
Sciences, University of Copenhagen, Copenhagen, Denmark
[6
]
Inserm U1110, Institut de Recherche sur les Maladies et Hépatiques, Strasbourg, France
[7
]
Université de Strasbourg, Strasbourg, France
[8
]
Pole Hépato-digestif, Institut Hospitalo-Universitaire, Hopitaux Universitaires de
Strasbourg, Strasbourg, France
Author notes
The authors have declared that no conflict of interest exists.
Author information
Article
Publisher ID:
PPATHOGENS-D-18-02108
DOI: 10.1371/journal.ppat.1007772
PMC ID: 6542541
PubMed ID: 31100098
SO-VID: b549a957-e3f5-4156-a745-bd821e3df34d
Copyright © © 2019 Keck et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: U19-AI123862, R21-AI26582, R01-AI132213,
Award Recipient
:
ORCID: http://orcid.org/0000-0001-7149-6160
Steven K. H. Foung
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: U19-AI123862
Award Recipient
:
Thomas F. Baumert
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: R21-AI126582, R01-AI132213
Award Recipient
:
Brian G. Pierce
Funded by: funder-id http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
Award ID: 222887, 1016351, 1043067
Award Recipient
:
Andrew R. Lloyd
Funded by: funder-id http://dx.doi.org/10.13039/501100000925, National Health and Medical Research Council;
Award ID: APP1084706
Award Recipient
:
ORCID: http://orcid.org/0000-0002-9844-3744
Rowena A. Bull
Funded by: funder-id http://dx.doi.org/10.13039/501100000781, European Research Council;
Award ID: AdG2014-HEPCIR, FP7 HepaMab and Interreg IVFEDER-Hepato-Regio-Net 2012
Award Recipient
:
Thomas F. Baumert
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: T32-AI125186
Award Recipient
:
Johnathan D. Guest
Funded by: Danish Council for Independent Research
Award ID: DFF-4004-00598
Award Recipient
:
ORCID: http://orcid.org/0000-0002-7815-4806
Jens Bukh
Funded by: funder-id http://dx.doi.org/10.13039/501100009708, Novo Nordisk Fonden;
Award ID: NNF17OC0029372
Award Recipient
:
Zhen-Yong Keck
This study was supported in part by NIH grants U19-AI123862 (SKHF and TFB), R21-AI126582
(BGP, SKHF), R01-AI132213 (BGP, SKHF), the Danish Council for Independent Research
DFF-4004-00598 (JB) and the Novo Nordisk Foundation NNF17OC0029372 (JB). The HITS-p
cohort has been supported by grants from National Health and Medical Resdearch Council
of Australia (NHMRC) (Nos. 222887 and 1016351), including NSW Health, Justice Health,
and Corrective Services NSW as partners. AL is supported by a NHMRC Practitioner Fellowship
(No. 1043067). RAB is supported by a NHMRC Career Development Fellowship (No. APP1084706).
TFB acknowledges grant support by the European Union (ERC-AdG-2014-HEPCIR, FP7 HepaMab
and Interreg IV FEDER-Hepato-Regio-Net 2012), the Agence Nationale de Recherche sur
le SIDA and LABEX ANR-10-LABX-0028-HEPSYS. JDG is supported by the University of Maryland
Virology Program graduate training grant (NIH T32-AI125186). This work was also supported
by the Australian Government Department of Health National Health and Medical Research
Council (NHMCR,
https://www.nhmrc.gov.au/) grants including NSW Health, Justice Health, and Corrective Services NSW as partners
(222887 and 1016351). The funders had no role in study design, data collection and
analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunoassays
Subject:
Enzyme-Linked Immunoassays
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Flaviviruses
Subject:
Hepacivirus
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Hepatitis viruses
Subject:
Hepatitis C virus
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Antibody Response
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune Response
Subject:
Antibody Response
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Virology
Subject:
Viral Transmission and Infection
Subject:
Viral Clearance
Subject:
Research and Analysis Methods
Subject:
Database and Informatics Methods
Subject:
Biological Databases
Subject:
Sequence Databases
Subject:
Research and Analysis Methods
Subject:
Database and Informatics Methods
Subject:
Bioinformatics
Subject:
Sequence Analysis
Subject:
Sequence Databases
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antigens
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Gene Mapping
Subject:
Epitope Mapping
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Gene Mapping
Subject:
Epitope Mapping