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      Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial.

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          Abstract

          Increased oxidative stress is important in the pathogenesis of chronic obstructive pulmonary disease (COPD). We postulated that treatment with the antioxidant N-acetylcysteine would reduce the rate of lung-function decline, reduce yearly exacerbation rate, and improve outcomes.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          1474-547X
          0140-6736
          May 4 2005
          : 365
          : 9470
          Affiliations
          [1 ] Respiratory Division, University Hospital, Katholieke Universiteit Leuven, Belgium. marc.decramer@uz.kuleuven.ac.be
          Article
          S0140-6736(05)66456-2
          10.1016/S0140-6736(05)66456-2
          15866309
          b34259da-9948-4a62-9935-9a6d273cdfef
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