Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves

Makkar, Raj R; Fontana, Gregory P; Jilaihawi, Hasan; Chakravarty, Tarun; Kofoed, Klaus F; De Backer, Ole; Asch, Federico M.; Ruiz, Carlos E.; Olsen, Niels T; Trento, Alfredo; Friedman, John; Berman, Daniel M.; Cheng, Wen; Kashif, Mohammad; Jelnin, Vladimir; Kliger, Chad A; Guo, Hongfei; Pichard, Augusto D; Weissman, Neil J; Kapadia, Samir N.; Manasse, Eric; Bhatt, Deepak L; Leon, Martin B; Søndergaard, Lars

doi:10.1056/NEJMoa1509233

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Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves

Author(s): Raj R. Makkar , Gregory Fontana , Hasan Jilaihawi , Tarun Chakravarty , Klaus F. Kofoed , Ole De Backer , Federico M. Asch , Carlos E. Ruiz , Niels T. Olsen , Alfredo Trento , John Friedman , Daniel Berman , Wen Cheng , Mohammad Kashif , Vladimir Jelnin , Chad A. Kliger , Hongfei Guo , Augusto D. Pichard , Neil J. Weissman , Samir Kapadia , Eric Manasse , Deepak L. Bhatt , Martin B. Leon , Lars Søndergaard

Publication date Created: November 19 2015

Publication date (Print): November 19 2015

Journal: New England Journal of Medicine

Publisher: Massachusetts Medical Society

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Abstract

A finding of reduced aortic-valve leaflet motion was noted on computed tomography (CT) in a patient who had a stroke after transcatheter aortic-valve replacement (TAVR) during an ongoing clinical trial. This finding raised a concern about possible subclinical leaflet thrombosis and prompted further investigation.

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Most cited references 6

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Transcatheter aortic valve replacement using a self-expanding bioprosthesis in patients with severe aortic stenosis at extreme risk for surgery.

Jeffrey J. Popma, David Adams, Michael J Reardon … (2014)

This study sought to evaluate the safety and efficacy of the CoreValve transcatheter heart valve (THV) for the treatment of severe aortic stenosis in patients at extreme risk for surgery.

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Treatment and clinical outcomes of transcatheter heart valve thrombosis.

Azeem Latib, Toru Naganuma, Mohamed Abdel-wahab … (2015)

Valve thrombosis has yet to be fully evaluated after transcatheter aortic valve implantation. This study aimed to report the prevalence, timing, and treatment of transcatheter heart valve (THV) thrombosis.

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Early aortic transcatheter heart valve thrombosis: diagnostic value of contrast-enhanced multidetector computed tomography.

Tina H Leetmaa, Nicolaj C Hansson, Jonathon A. Leipsic … (2015)

Early stent valve thrombosis after transcatheter aortic valve implantation (TAVI) is a rare complication, which is diagnosed based on the appearance of clinical symptoms of heart failure and echocardiographic findings. After TAVI, transthoracic echocardiography is performed to assess transcatheter heart valve (THV) function. However, preliminary reports indicate the potential additive clinical value of multidetector computed tomography (MDCT) for the diagnosis of THV thrombosis. We sought to determine the value of MDCT for the diagnosis of THV thrombosis and the frequency of this complication after balloon-expandable TAVI.