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      Quality of life and well-being problems in secondary schoolgirls in Kenya: Prevalence, associated characteristics, and course predictors

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          Abstract

          Background

          Adolescents in sub-Saharan Africa often report low levels of quality of life (QoL) and well-being, but reliable data are limited. This study examines which sociodemographic, health, and behavioral risk factors and adverse adolescent experiences are associated with, and predictive of, QoL in Kenyan secondary schoolgirls.

          Methods and findings

          3,998 girls at baseline in a randomised controlled trial in Siaya County, western Kenya were median age 17.1 years. Subjectively perceived physical, emotional, social and school functioning was assessed using the Pediatric Quality of Life (QoL) Inventory-23. Laboratory-confirmed and survey data were utilized to assess sociodemographic, health and behavioral characteristics, and adverse adolescent experiences. We identified a group of girls with Low QoL (n = 1126; 28.2%), Average QoL (n = 1445; 36.1%); and High QoL (n = 1427; 35.7%). Significantly higher scores on all well-being indicators in the LQoL compared with HQoL group indicated good construct validity (Odds Ratio’s (ORs) varying from 3.31 (95% CI:2.41–4.54, p < .001) for feeling unhappy at home to 11.88 (95%CI:7.96–17.74, p< .001) for PHQ9 defined possible caseness (probable diagnosis) of depression. Adverse adolescent experiences were independently statistically significant in the LQoL compared to the HQoL group for threats of family being hurt (aOR = 1.35,1.08–1.68, p = .008), sexual harassment out of school (aOR = 2.17,1.79–2.64, p < .001), and for menstrual problems like unavailability of sanitary pads (aOR = 1.23,1.05–1.44, p = .008) and stopping activities due to menstruation (aOR = 1.77,1.41–2.24, p < .001). After 2-years follow-up of 906 girls in the LQoL group, 22.7% persisted with LQoL. Forced sex (aOR = 1.56,1.05–2.32, p = .028) and threats of family being hurt (aOR = 1.98,1.38–2.82, p < .001) were independent predictors of persistent LQoL problems.

          Conclusions

          Persistent QoL problems in Kenyan adolescent girls are associated with adverse physical, sexual and emotional experiences and problems with coping with their monthly menstruation. A multi-factorial integral approach to reduce the rate of adverse adolescent experiences is needed, including provision of menstrual hygiene products.

          Trial registration

          ClinicalTrials.gov: NCT03051789.

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          Most cited references45

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          The PHQ-9: validity of a brief depression severity measure.

          While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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            The PHQ-9

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              Deciding on the Number of Classes in Latent Class Analysis and Growth Mixture Modeling: A Monte Carlo Simulation Study

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                Author and article information

                Contributors
                Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: VisualizationRole: Writing – original draftRole: Writing – review & editing
                Role: Data curationRole: InvestigationRole: MethodologyRole: SupervisionRole: ValidationRole: Writing – review & editing
                Role: InvestigationRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: Writing – review & editing
                Role: Data curationRole: MethodologyRole: ValidationRole: Writing – review & editing
                Role: Data curationRole: MethodologyRole: ResourcesRole: ValidationRole: Writing – review & editing
                Role: Project administrationRole: ResourcesRole: ValidationRole: Writing – review & editing
                Role: MethodologyRole: ValidationRole: Writing – review & editing
                Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole: SupervisionRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Writing – review & editing
                Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: MethodologyRole: SupervisionRole: Writing – review & editing
                Role: Editor
                Journal
                PLOS Glob Public Health
                PLOS Glob Public Health
                plos
                PLOS Global Public Health
                Public Library of Science (San Francisco, CA USA )
                2767-3375
                19 December 2022
                2022
                : 2
                : 12
                : e0001338
                Affiliations
                [1 ] Institute of Psychology, Leiden University, Leiden, The Netherlands
                [2 ] Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands
                [3 ] Liverpool School of Tropical Medicine (LSTM), Liverpool, United Kingdom
                [4 ] Centre for Global Health, Kenya Medical Research Institute (KEMRI), Kisumu, Kenya
                [5 ] Ministry of Health, Siaya County, Kenya
                Bangladesh University of Health Sciences, BANGLADESH
                Author notes

                The authors have declared that no competing interests exist.

                Author information
                https://orcid.org/0000-0002-4117-335X
                https://orcid.org/0000-0002-2852-6368
                https://orcid.org/0000-0002-4873-6151
                https://orcid.org/0000-0003-1018-116X
                Article
                PGPH-D-22-01029
                10.1371/journal.pgph.0001338
                10022324
                36962912
                aca2b6be-714d-48f5-934f-9eee43cfc6db
                © 2022 Spinhoven et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 25 June 2022
                : 8 November 2022
                Page count
                Figures: 1, Tables: 4, Pages: 17
                Funding
                Funded by: Joint Global Health Trials Initiative
                Award ID: MR/N006046/1
                Award Recipient :
                This work is part of the Cups or Cash for Girls randomised-controlled trial funded by the Joint Global Health Trials Initiative (UK-Medical Research Council (MRC), the Foreign, Commonwealth & Development Office (FCDO), Wellcome, and the Department of Health and Social Care (DHSC) – https://www.ukri.org/opportunity/joint-global-health-trials/). PPH, DK, and DW received the award, grant MR/N006046/1. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Social Sciences
                Sociology
                Education
                Schools
                People and Places
                Population Groupings
                Age Groups
                Children
                Adolescents
                People and Places
                Population Groupings
                Families
                Children
                Adolescents
                Medicine and Health Sciences
                Mental Health and Psychiatry
                Medicine and Health Sciences
                Epidemiology
                Medical Risk Factors
                Biology and Life Sciences
                Psychology
                Emotions
                Social Sciences
                Psychology
                Emotions
                Medicine and Health Sciences
                Health Care
                Quality of Life
                Social Sciences
                Economics
                Finance
                Medicine and Health Sciences
                Mental Health and Psychiatry
                Child Psychiatry
                Custom metadata
                This study was conducted with approval from the Kenya Medical Research Institute (KEMRI) Scientific and Ethics Review Unit (SERU), which requires that data be released from any KEMRI-based Kenyan studies (including de-identified data) only after their written approval for additional analyses. In accordance, data for this study will be available upon request, after obtaining written approval for the proposedanalysis from the KEMRI SERU. Their application forms and guidelines can be accessed at https://www.kemri.org/seru-overview. To request these data, please contact the KEMRI SERU at seru@ 123456kemri.org .

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