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Vitamin B12 supplementation during pregnancy and postpartum improves B12 status of both mothers and infants but vaccine response in mothers only: a randomized clinical trial in Bangladesh.
Towfida J Siddiqua
1
,
2 ,
Shaikh M Ahmad
1 ,
Khalid B Ahsan
1 ,
Mamunur Rashid
1 ,
Anjan Roy
1 ,
Syed M Rahman
1 ,
Setareh Shahab-Ferdows
3 ,
Daniela Hampel
3
,
2 ,
Tahmeed Ahmed
1 ,
Lindsay H Allen
3
,
2 ,
Rubhana Raqib
4
Feb 2016
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Abstract
Poor vitamin B12 (B12) status is associated with adverse outcomes in pregnancy and infancy. Little is known about effects of B12 supplementation on immune function. The present study aimed to evaluate effects of pre- and postnatal B12 supplementation on biomarkers of B12 status and vaccine-specific responses in mothers and infants.