Combined effects of vitamin D and neferine on the progression and metastasis of colorectal cancer

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Abstract

Purpose

To investigate the synergistic effect of vitamin D and neferine on the growth and metastasis of colorectal cancer (CRC).

Methods

The synergistic effect of biologically active form of vitamin D, VD ₃ and neferine on the treatment of CRC was investigated by bliss analysis. Colony formation and wound healing ability, migration and invasion ability, and epithelial mesenchymal transition of HCT-116 cells, as a response to the combination treatment with VD ₃ and neferine were evaluated.

Results

VD ₃ and neferine showed a synergistic effect on CRC cell growth at a relatively low dose. The wound healing and colony formation capacity, cell migration and invasion abilities were all decreased by combination use of VD ₃ and neferine, compared to the VD ₃ or neferine treated single group. Furthermore, VD ₃ and neferine significantly decreased the expressions of N-cadherin, vimentin, snail, and slug in HCT-116 cells.

Conclusion

These data suggest that neferine enhances the anticancer capability of VD ₃ and reduces the dose dependency of VD ₃. The combination of vitamin D with neferine appears to be a potential therapeutic strategy for CRC.

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Most cited references 21

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Colorectal Cancer and Nutrition

Kannan Thanikachalam, Gazala Khan (2019)

Colorectal Cancer is the third most common cancer diagnosed in the US. While the incidence and the mortality rate of colorectal cancer has decreased due to effective cancer screening measures, there has been an increase in number of young patients diagnosed in colon cancer due to unclear reasons at this point of time. While environmental and genetic factors play a major role in the pathogenesis of colon cancer, extensive research has suggested that nutrition may play both a causal and protective role in the development of colon cancer. In this review article, we aim to provide a review of factors that play a major role in development of colorectal cancer.

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The role of vitamin D in reducing cancer risk and progression.

David Feldman, Aruna Krishnan, Srilatha Swami … (2014)

Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol, which has widespread actions throughout the body. Calcitriol regulates numerous cellular pathways that could have a role in determining cancer risk and prognosis. Although epidemiological and early clinical trials are inconsistent, and randomized control trials in humans do not yet exist to conclusively support a beneficial role for vitamin D, accumulating results from preclinical and some clinical studies strongly suggest that vitamin D deficiency increases the risk of developing cancer and that avoiding deficiency and adding vitamin D supplements might be an economical and safe way to reduce cancer incidence and improve cancer prognosis and outcome.

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Protective links between vitamin D, inflammatory bowel disease and colon cancer.

Stacey Meeker, Audrey Seamons, Lillian Maggio-Price … (2016)

Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease (IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer.

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Author and article information

Contributors

Lihua Zhou: 2640627607@qq.com

Jiamin Jin:

ORCID: http://orcid.org/0000-0001-9141-3350

jinjiamin@glmc.edu.cn

Journal

Journal ID (nlm-ta): J Cancer Res Clin Oncol

Journal ID (iso-abbrev): J Cancer Res Clin Oncol

Title: Journal of Cancer Research and Clinical Oncology

Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )

ISSN (Print): 0171-5216

ISSN (Electronic): 1432-1335

Publication date (Electronic): 26 January 2023

Publication date PMC-release: 26 January 2023

Publication date (Print): 2023

Volume: 149

Issue: 9

Pages: 6203-6210

Affiliations

[1 ]GRID grid.443385.d, ISNI 0000 0004 1798 9548, School of Pharmacy, , Guilin Medical University, ; Guilin, 541199 China

[2 ]GRID grid.443385.d, ISNI 0000 0004 1798 9548, Key Laboratory of Tumor Immunology and Microenvironmental Regulation, , Guilin Medical University, ; Guilin, 541199 China

[3 ]GRID grid.443385.d, ISNI 0000 0004 1798 9548, Department of Immunology, , Guilin Medical University, ; Guilin, 541199 China

[4 ]GRID grid.443385.d, ISNI 0000 0004 1798 9548, Guangxi Health Commission Key Laboratory of Tumor Immunology and Receptor-Targeted Drug Basic Research, , Guilin Medical University, ; Guilin, 541199 China

[5 ]GRID grid.443385.d, ISNI 0000 0004 1798 9548, Department of Gastrointestinal Surgery, , Affiliated Hospital of Guilin Medical University, ; Guilin, 541000 China

Author information

Jiamin Jin http://orcid.org/0000-0001-9141-3350

Article

Publisher ID: 4552

DOI: 10.1007/s00432-022-04552-7

PMC ID: 10356635

PubMed ID: 36697773

SO-VID: a875cd85-9740-4fa6-a0e3-8d005b2e5c01

License:

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 19 November 2022

Date accepted : 21 December 2022

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100004607, Natural Science Foundation of Guangxi Province;

Award ID: 2020GXNSFBA297004

Award Recipient : Jinfeng Yang

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: 82100234

Award ID: 82260602; 82204208

Award Recipient : Jinfeng Yang Juzheng Zhang Guangying Qi

Funded by: 2019 BaGui Scholars Program of Guangxi Zhuang Autonomous Region

Award ID: 203030302212

Award Recipient : Jiamin Jin

Custom metadata

ScienceOpen disciplines: Oncology & Radiotherapy

Keywords: vitamin d3,neferine,colorectal cancer,migration,invasion

Data availability:

ScienceOpen disciplines: Oncology & Radiotherapy

Keywords: vitamin d3, neferine, colorectal cancer, migration, invasion

Combined effects of vitamin D and neferine on the progression and metastasis of colorectal cancer

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Abstract

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Karger: Oncology

Most cited references 21

Colorectal Cancer and Nutrition

The role of vitamin D in reducing cancer risk and progression.

Protective links between vitamin D, inflammatory bowel disease and colon cancer.

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