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      Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).

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          Abstract

          Current standard of care requires that HER2 gene testing be performed on all newly diagnosed invasive breast cancers in order to determine eligibility for anti-HER2 antibody therapy and should be performed in accordance with current ASCO-CAP guidelines (Hammond et al., J Clin Oncol 29(15):e458, 2011; Wolff et al., J Clin Oncol 31(31):3997-4013, 2013). Here we describe a HER2 FISH methodology to evaluate HER2 gene status in FFPE breast tumor specimens.

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          Author and article information

          Journal
          Methods Mol Biol
          Methods in molecular biology (Clifton, N.J.)
          Springer Science and Business Media LLC
          1940-6029
          1064-3745
          2016
          : 1406
          Affiliations
          [1 ] Department of Molecular Pathology, PhenoPath Laboratories, 551 North 34th Street, Seattle, WA, 98103-8675, USA. hhwang@phenopath.com.
          [2 ] Department of Molecular Pathology, PhenoPath Laboratories, 551 North 34th Street, Seattle, WA, 98103-8675, USA.
          Article
          10.1007/978-1-4939-3444-7_5
          26820945
          a7e940c1-a987-46d0-8c4a-6212b223d60c
          History

          Fluorescence in situ hybridization,HER2,PathVysion,Human epidermal growth factor receptor 2,Herceptin,Breast cancer,DNA probe,FISH

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