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Abstract
Silver foxes selected for more than 30 years for tame behavior and displaying no defensive
reaction to human contact were shown to have a higher serotonin level in midbrain
and hypothalamus, and a higher 5-hydroxyindole acetic acid (5-HIAA) content in midbrain,
hypothalamus and hippocampus in comparison to nonselected wild silver foxes bred in
captivity over the same time span. Tryptophan hydroxylase (TPH) activity in midbrain
and hypothalamus in domesticated foxes was increased as compared with their aggressive/defensive
counterparts. Monoamine oxidase type A (MAO A) activity was was decreased with an
increased Km and unchanged Vmax in domesticated foxes. No changes in specific [3H]ketanserin
or [3H]8-OH-DPAT binding in frontal cortex was revealed. A reduced density (Bmax)
of 5HT1A receptors in hypothalamic membranes in domesticated foxes was shown. It is
suggested that the brain serotonergic system is involved in the mechanism of domestication
converting wild aggressive/defensive animals into tame ones.