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Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease.
C H Hennekens
1 ,
J E Buring ,
J E Manson ,
M Stampfer ,
B Rosner ,
N R Cook ,
C Belanger ,
F LaMotte ,
J M Gaziano ,
P M Ridker ,
W Willett ,
R Peto
May 02 1996
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Abstract
Observational studies suggest that people who consume more fruits and vegetables containing beta carotene have somewhat lower risks of cancer and cardiovascular disease, and earlier basic research suggested plausible mechanisms. Because large randomized trials of long duration were necessary to test this hypothesis directly, we conducted a trial of beta carotene supplementation.