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      γ-Cyclodextrin Inclusion of Phloroglucinol: Solid State Studies and Antioxidant Activity throughout the Digestive Tract

      , , , , ,
      Applied Sciences
      MDPI AG

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          Abstract

          Phloroglucinol is a powerful antioxidant compound and an active pharmaceutical ingredient used in the management of intestinal spasms. In this report, we describe the interaction of γ-cyclodextrin with phloroglucinol to readily form a solid inclusion compound with 1:1 by co-dissolution and freeze-drying. Solid-state characterisation using FT-IR, thermal analyses (TGA and DTA) and X-ray powder diffraction confirmed the formation of a true inclusion compound (γ-CD·PG) in which the molecules of γ-CD are stacked into channels. This spatial arrangement is typical of γ-CD inclusion compounds, and it allows for the guest molecules to be located inside these channels. The evaluation of the antiradical potential of γ-CD·PG (against O2•− and NO•) on different steps of the digestive process (mouth, gastric and intestinal phases) led us to conclude that the inclusion of phloroglucinol promoted better antioxidant activity at the end of the digestion when compared to the free phloroglucinol.

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          Most cited references43

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          Biomimetic Reactions Catalyzed by Cyclodextrins and Their Derivatives.

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            Phloroglucinol compounds of natural origin.

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              NMR Studies of Cyclodextrins and Cyclodextrin Complexes.

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                Author and article information

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                Journal
                ASPCC7
                Applied Sciences
                Applied Sciences
                MDPI AG
                2076-3417
                March 2022
                February 23 2022
                : 12
                : 5
                : 2340
                Article
                10.3390/app12052340
                a27659e8-8783-4c78-9217-fe025c73aac9
                © 2022

                https://creativecommons.org/licenses/by/4.0/

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