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Robust hepatitis C virus infection in vitro.
Jin Zhong
1 ,
Pablo Gastaminza ,
Guofeng Cheng ,
Sharookh Kapadia ,
Takanobu Kato ,
Dennis R Burton ,
Stefan F Wieland ,
Susan L Uprichard ,
Takaji Wakita ,
Francis V Chisari
Jun 28 2005
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Abstract
The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we report the establishment of a simple yet robust HCV cell culture infection system based on the HCV JFH-1 molecular clone and Huh-7-derived cell lines that allows the production of virus that can be efficiently propagated in tissue culture. This system provides a powerful tool for the analysis of host-virus interactions that should facilitate the discovery of antiviral drugs and vaccines for this important human pathogen.