Glial cell line-derived neurotrophic factor is constitutively produced by human testicular peritubular cells and may contribute to the spermatogonial stem cell niche in man.

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Abstract

Testicular peritubular cells form an ill-characterized cellular compartment of the human testis, which forms a border with Sertoli cells and spermatogonial stem cells (SSCs). A recently developed culture method has identified parts of the secretory repertoire of human testicular peritubular cells (HTPCs), which includes nerve growth factor. Whether peritubular cells produce glial cell line-derived neurotrophic factor (GDNF) and may thus contribute to the stem cell niche is not known.

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Journal

Journal ID (iso-abbrev): Hum. Reprod.

Title: Human reproduction (Oxford, England)

ISSN (Electronic): 1460-2350

ISSN (Print): 0268-1161

Publication date (Electronic): Sep 2010

Volume: 25

Issue: 9

Affiliations

[1 ] Institute for Cell Biology, Anatomy and Center for Integrated Protein Science Munich (CIPSM), Ludwig Maximilian University, Biedersteiner Strasse 29, D-80802 Munich, Germany.

Article

Publisher Item ID: deq170

DOI: 10.1093/humrep/deq170

PubMed ID: 20601681

SO-VID: 9472e061-fbbc-4371-b932-c0ea41a25cb3

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