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      Can PM 2.5 pollution worsen the death rate due to COVID-19 in India and Pakistan?

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          Abstract

          There is growing evidence of a positive correlation between PM2.5 pollution and COVID-19, suggesting that mitigation of PM2.5 will be a decisive step towards easing out the lockdown over India and Pakistan. PM2.5 is a bothering factor for both countries experiencing the worst air pollution in the world. According to the World Air Quality Report (2018), 22 cities in India and two cities in Pakistan are among the world's top 30 most polluted cities (IQAir AirVisual, 2018). Recently, it has been estimated that 645,000 premature deaths in India, and 111,000 in Pakistan, are recorded every year (Lelieveld et al., 2015). The direct cost of environmental damages associated with the regional air pollution exceeds US$ 0.5 trillion in India and US$ 1.07 billion in Pakistan (Sanchez-Triana et al., 2014; OECD, 2014). The World Health Organization (WHO) has notified that persons of any age group, who suffer from severe underlying medical conditions, are at a higher risk of getting critically sick from COVID-19. Certain preconditions, including lung cancer, and the respiratory or cardiovascular disorders are triggered by air pollution, and the residents of the region with high levels of PM2.5 before the Corona pandemic are more vulnerable to the infection in comparison to patients in cleaner parts of the world, reports WHO. Persons suffering from cardiovascular and chronic respiratory diseases like asthma and those immunocompromised due to conditions like smoking or cancer, etc., are more susceptible to Corona virus infection (WHO, 2020). A research conducted by Cui et al. (2003) during the SARS (Severe Acute Respiratory Syndrome) epidemic in China highlighted that SARS, caused by a virus genetically identical to COVID-19, caused high mortality in areas with deteriorated air quality. In a recent study in China, a substantial relationship has been found between PM2.5 and COVID-19 infection, which was reported across 120 cities (Zhu and Xie, 2020). It was noted that a 10 μgm−3 increase in pollution concentration led to a statistically significant increase in daily counts of the confirmed symptomatic Corona-positive cases. Wu et al. (2020) at the Harvard University T.H. Chan School of Public Health have suggested that an increase of just 1 μgm−3 of PM2.5 corresponds to a 15% increase in COVID-19 deaths. Another study that establishes the relationship of higher COVID-19 mortality and morbidity to PM2.5 in northern Italy provides a piece of sharp evidence that persons living in an area with high levels of PM2.5 are more susceptible to developing respiratory diseases, which facilitate the impact of any infectious agent, especially in children and unhealthy population (Mehmood et al., 2020; Conticini et al., 2020). Recently, transboundary air pollution in this region has resulted in an exceptionally high PM2.5 concentration of 1000 μg m−3 in Lahore (Malik, 2017) and 700 μg m−3 in New Delhi (Anand, 2016). These levels are 40 and 28 times higher, respectively than the average daily PM2.5 level of 25 μg m−3, as established by the World Health Organization (WHO). After May 2020, the Pakistan and Indian governments have started to ease the lockdown restrictions, which were imposed to curtail the COVID-19 pandemic. They are trying to resume normal life in the larger more substantial interest of both the nations already perturbed with their crumbling economies. Industrial productions, public transport as well as construction sites have already resumed their operation in most of the Pakistani provinces and Indian states with implementation of social distancing and personal hygiene practices. According to the WHO official COVID-19 data, India is now the 4th worst affected country by COVID-19 with more than 395,048 infected cases and 12,948 deaths till June 20. In comparison, Pakistan has so far recorded over 171,666 cases of infection with 3382 deaths. There is a reason for the hope that the two governments can find common ground and resolve together to reduce PM2.5 pollution to improve the health condition of their citizens on both sides of the border. We suggest that multi-pronged efforts be urgently initiated in both the countries to avoid the worse disaster of the current pandemic in the days to follow. Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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          Association between short-term exposure to air pollution and COVID-19 infection: Evidence from China

          The novel coronavirus pneumonia, namely COVID-19, has become a global public health problem. Previous studies have found that air pollution is a risk factor for respiratory infection by carrying microorganisms and affecting body's immunity. This study aimed to explore the relationship between ambient air pollutants and the infection caused by the novel coronavirus. Daily confirmed cases, air pollution concentration and meteorological variables in 120 cities were obtained from January 23, 2020 to February 29, 2020 in China. We applied a generalized additive model to investigate the associations of six air pollutants (PM2.5, PM10, SO2, CO, NO2 and O3) with COVID-19 confirmed cases. We observed significantly positive associations of PM2.5, PM10, NO2 and O3 in the last two weeks with newly COVID-19 confirmed cases. A 10-μg/m3 increase (lag0–14) in PM2.5, PM10, NO2, and O3 was associated with a 2.24% (95% CI: 1.02 to 3.46), 1.76% (95% CI: 0.89 to 2.63), 6.94% (95% CI: 2.38 to 11.51), and 4.76% (95% CI: 1.99 to 7.52) increase in the daily counts of confirmed cases, respectively. However, a 10-μg/m3 increase (lag0–14) in SO2 was associated with a 7.79% decrease (95% CI: −14.57 to −1.01) in COVID-19 confirmed cases. Our results indicate that there is a significant relationship between air pollution and COVID-19 infection, which could partially explain the effect of national lockdown and provide implications for the control and prevention of this novel disease.
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            Can atmospheric pollution be considered a co-factor in extremely high level of SARS-CoV-2 lethality in Northern Italy? ☆

            This paper investigates the correlation between the high level of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) lethality and the atmospheric pollution in Northern Italy. Indeed, Lombardy and Emilia Romagna are Italian regions with both the highest level of virus lethality in the world and one of Europe’s most polluted area. Based on this correlation, this paper analyzes the possible link between pollution and the development of acute respiratory distress syndrome and eventually death. We provide evidence that people living in an area with high levels of pollutant are more prone to develop chronic respiratory conditions and suitable to any infective agent. Moreover, a prolonged exposure to air pollution leads to a chronic inflammatory stimulus, even in young and healthy subjects. We conclude that the high level of pollution in Northern Italy should be considered an additional co-factor of the high level of lethality recorded in that area.
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              Can exposure to PM 2.5 particles increase the incidence of coronavirus disease 2019 (COVID-19)?

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                Author and article information

                Contributors
                Journal
                Sci Total Environ
                Sci. Total Environ
                The Science of the Total Environment
                Elsevier B.V.
                0048-9697
                1879-1026
                27 June 2020
                10 November 2020
                27 June 2020
                : 742
                : 140557
                Affiliations
                [a ]Research Center for Air Pollution and Health and the MOE Key Laboratory of Environment Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
                [b ]Institute of Soil and Environmental Sciences, University of Agriculture, Faisalabad 38040, Pakistan
                [c ]National Engineering Laboratory for Improving Quality of Arable Land, Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences, Beijing 100081, PR China
                [d ]Jamia Hamdard (Deemed University), New Delhi 110062, India
                [e ]Department of Veterinary Pathology, Faculty of Veterinary Science, University of Agriculture Faisalabad, Pakistan
                [f ]Miami Valley Hospital, Dayton, OH, United States of America
                Author notes
                [* ]Corresponding author at: Research Center for Air Pollution and Health and the MOE Key Laboratory of Environment Remediation and Ecosystem Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, PR China khalid_mehmood@ 123456zju.edu.cn sipra.khalid@ 123456yahoo.com
                Article
                S0048-9697(20)34079-1 140557
                10.1016/j.scitotenv.2020.140557
                7320254
                931c7f49-e685-4170-954c-ee95b3973d80
                © 2020 Elsevier B.V. All rights reserved.

                Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

                History
                : 20 June 2020
                : 25 June 2020
                : 25 June 2020
                Categories
                Article

                General environmental science
                pm2.5,covid-19
                General environmental science
                pm2.5, covid-19

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