3
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      From Altered States to Metaphysics: The Epistemic Status of Psychedelic-induced Metaphysical Beliefs

      Review of Philosophy and Psychology
      Springer Science and Business Media LLC

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Psychedelic substances elicit powerful, uncanny conscious experiences that are thought to possess therapeutic value. In those who undergo them, these altered states of consciousness often induce shifts in metaphysical beliefs about the fundamental structure of reality. The contents of those beliefs range from contentious to bizarre, especially when considered from the point of view of naturalism. Can chemically induced, radically altered states of consciousness provide reasons for or play some positive epistemic role with respect to metaphysical beliefs? In this paper, I discuss a view that has been underexplored in recent literature. I argue that psychedelic states can be rationally integrated into one’s epistemic life. Consequently, updating one’s metaphysical beliefs based on altered states of consciousness does not have to constitute an instance of epistemic irrationality.

          Related collections

          Most cited references68

          • Record: found
          • Abstract: found
          • Article: not found

          Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance.

          Although psilocybin has been used for centuries for religious purposes, little is known scientifically about its acute and persisting effects. This double-blind study evaluated the acute and longer-term psychological effects of a high dose of psilocybin relative to a comparison compound administered under comfortable, supportive conditions. The participants were hallucinogen-naïve adults reporting regular participation in religious or spiritual activities. Two or three sessions were conducted at 2-month intervals. Thirty volunteers received orally administered psilocybin (30 mg/70 kg) and methylphenidate hydrochloride (40 mg/70 kg) in counterbalanced order. To obscure the study design, six additional volunteers received methylphenidate in the first two sessions and unblinded psilocybin in a third session. The 8-h sessions were conducted individually. Volunteers were encouraged to close their eyes and direct their attention inward. Study monitors rated volunteers' behavior during sessions. Volunteers completed questionnaires assessing drug effects and mystical experience immediately after and 2 months after sessions. Community observers rated changes in the volunteer's attitudes and behavior. Psilocybin produced a range of acute perceptual changes, subjective experiences, and labile moods including anxiety. Psilocybin also increased measures of mystical experience. At 2 months, the volunteers rated the psilocybin experience as having substantial personal meaning and spiritual significance and attributed to the experience sustained positive changes in attitudes and behavior consistent with changes rated by community observers. When administered under supportive conditions, psilocybin occasioned experiences similar to spontaneously occurring mystical experiences. The ability to occasion such experiences prospectively will allow rigorous scientific investigations of their causes and consequences.
            Bookmark
            • Record: found
            • Abstract: not found
            • Book: not found

            The varieties of religious experience: A study in human nature.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics

              This paper formulates the action of psychedelics by integrating the free-energy principle and entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics (REBUS) and the anarchic brain, founded on the principle that—via their entropic effect on spontaneous cortical activity—psychedelics work to relax the precision of high-level priors or beliefs, thereby liberating bottom-up information flow, particularly via intrinsic sources such as the limbic system. We assemble evidence for this model and show how it can explain a broad range of phenomena associated with the psychedelic experience. With regard to their potential therapeutic use, we propose that psychedelics work to relax the precision weighting of pathologically overweighted priors underpinning various expressions of mental illness. We propose that this process entails an increased sensitization of high-level priors to bottom-up signaling (stemming from intrinsic sources), and that this heightened sensitivity enables the potential revision and deweighting of overweighted priors. We end by discussing further implications of the model, such as that psychedelics can bring about the revision of other heavily weighted high-level priors, not directly related to mental health, such as those underlying partisan and/or overly-confident political, religious, and/or philosophical perspectives. Significance Statement Psychedelics are capturing interest, with efforts underway to bring psilocybin therapy to marketing authorisation and legal access within a decade, spearheaded by the findings of a series of phase 2 trials. In this climate, a compelling unified model of how psychedelics alter brain function to alter consciousness would have appeal. Towards this end, we have sought to integrate a leading model of global brain function, hierarchical predictive coding, with an often-cited model of the acute action of psychedelics, the entropic brain hypothesis. The resulting synthesis states that psychedelics work to relax high-level priors, sensitising them to liberated bottom-up information flow, which, with the right intention, care provision and context, can help guide and cultivate the revision of entrenched pathological priors.
                Bookmark

                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Review of Philosophy and Psychology
                Rev.Phil.Psych.
                Springer Science and Business Media LLC
                1878-5158
                1878-5166
                October 10 2023
                Article
                10.1007/s13164-023-00709-6
                9270fc55-1437-4215-9575-ec3887046b13
                © 2023

                https://creativecommons.org/licenses/by/4.0

                https://creativecommons.org/licenses/by/4.0

                History

                Comments

                Comment on this article