Contributors
Silvia Messina: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Writing – original
draftRole: Writing – review & editing
Claudio Solaro: Role: ConceptualizationRole: Data curationRole: InvestigationRole: Writing – review
& editing
Isabella Righini: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Roberto Bergamaschi: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Simona Bonavita: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Roberto Bruno Bossio: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Vincenzo Brescia Morra: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Gianfranco Costantino: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Paola Cavalla: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Diego Centonze: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Giancarlo Comi: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Salvatore Cottone: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Maura Chiara Danni: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Ada Francia: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Alberto Gajofatto: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Claudio Gasperini: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Mauro Zaffaroni: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Loredana Petrucci: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Elisabetta Signoriello: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Giorgia Teresa Maniscalco: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Gabriella Spinicci: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Manuela Matta: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Massimiliano Mirabella: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Graziella Pedà: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Letizia Castelli: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Marco Rovaris: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Edoardo Sessa: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Daniele Spitaleri: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Damiano Paolicelli: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Alfredo Granata: Role: Formal analysisRole: InvestigationRole: Writing – review & editing
Mario Zappia: Role: InvestigationRole: ValidationRole: Writing – review & editing
Francesco Patti:
ORCID: http://orcid.org/0000-0002-6923-0846
Role: ConceptualizationRole: Data curationRole: InvestigationRole: Project administrationRole:
ValidationRole: Writing – original draftRole: Writing – review & editing
Orhan Aktas: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
1
August
2017
Publication date Collection: 2017
Volume: 12
Issue: 8
Electronic Location Identifier: e0180651
Affiliations
[1
]
Department of Medical, Surgical Science and Advanced Technology "GF Ingrassia"–University
of Catania, Catania, Italy
[2
]
Neurology Unit, Department Head And Neck, ASL3 Genova, Italy
[3
]
Department NEUROFARBA—University of Florence, Florence, Italy
[4
]
Department of Neurology—Neurology Institute C Mondino, Pavia, Italy
[5
]
I clinic Neurology—II University of Naples, Naples, Italy
[6
]
Neurology Operating Unit and Multiple Sclerosis Center—Provincial Health Authority
of Cosenza, Cosenza, Italy
[7
]
Multiple Sclerosis Centre—University Federico II, Naples, Italy
[8
]
Demyelinating Diseases Centre—Foggia Hospital, Foggia, Italy
[9
]
A.O.U: Cittàdella Salute e dellaScienza di Torino, Torino, Italy
[10
]
Neuroscience Department—University Tor Vegata, Rome, Italy
[11
]
Unit of Neurology and of Neurorehabilitation, IRCCS Neuromed, Pozzilli (IS), Italy
[12
]
Department of Neurology–San Raffaele Hospital, Milan, Italy
[13
]
Neuroimmunology Unit—Villa Sofia-Cervello Hospital, Palermo, Italy
[14
]
Neurology Clinic—Ancona Hospital, Ancona, Italy
[15
]
Multiple Sclerosis Center, Dept. Neurol. Psich—Sapienza University, Rome, Italy
[16
]
Department of Neuroscience, Biomedicine and Movement Multiple Sclerosis Centre–University
of Verona, Verona, Italy
[17
]
Neurology Division—San Camillo Hospital, Rome, Italy
[18
]
Multiple Sclerosis Centre—Sant'Antonio Abate Hospital, Gallarate, Italy
[19
]
Multiple Sclerosis Centre—University Hospital Pisa, Pisa, Italy
[20
]
Multiple Sclerosis Center—Second University of Naples, Naples, Italy
[21
]
Multiple Sclerosis Centre—Cardarelli Hospital, Naples, Italy
[22
]
Department of Medical Sciences—University of Cagliari, Cagliari, Italy
[23
]
Multiple Sclerosis Centre (CRESM)—San Luigi Gonzaga Hospital, Orbassano, Italy
[24
]
Multiple Sclerosis Centre—Cattolica University, Rome, Italy
[25
]
Multiple Sclerosis Centre—Vaio Hospital, Fidenza, Italy
[26
]
Multiple Sclerosis Centre—S. Andrea Hospital, Rome, Italy
[27
]
Multiple Sclerosis Centre—IRCCS Don Gnocchi Foundation, Milan, Italy
[28
]
Multiple Sclerosis Centre—IRCCS-Bonino Pulejo Centre, Messina, Italy
[29
]
Multiple Sclerosis Centre—San G. Moscati Hospital, Avellino, Italy
[30
]
Department of Basic Medical Sciences, Neuroscience and Sense Organs—University of
Bari “Aldo Moro” Bari, Italy
[31
]
Department of Medical Sciences, Institute of Neurology—University “Magna Graecia”,
Catanzaro, Italy
Heinrich-Heine-Universitat Dusseldorf, GERMANY
Author notes
Competing Interests: Dr Messina has received honoraria for scientific lectures form Biogen, Almirall, travel
payment from Novartis, Biogen Idec, Genzyme, Almirall Bayer Schering, Merck Serono,
Teva, and she serves on a scientific advisory board for Biogen. Dr Solaro received
honoraria from Biogen, Genzyme, Novartis, Merck Serono, Almirall, Teva. Dr Righini
has nothing to disclose. Dr Bergamaschi has received honoraria for scientific lectures
and travel payment from Biogen, Novartis, Teva, Genzyme, Bayer Schering, Merck Serono,
Almirall. Prof Bonavita received speaker and advisory board honoraria from Biogen,
Novartis and Merck-Serono. Dr Bruno Bossio received a grant for advisory board activities
from Almirall. Dr Brescia Morra has received honoraria for scientific lectures and
travel payment from Biogen, Novartis, Teva, Genzyme, Bayer Schering, Merck Serono,
Almirall. Dr Costantino reveived honoraria for speaking activities from Genzyme, Merck-Serono,
Biogen and Novartis. Dr Cavalla has nothing to disclose. Prof DiegoCentonze is an
Advisory Board member of Almirall, Bayer Schering, Biogen, Genzyme, GW Pharmaceuticals,
Merck-Serono, Novartis, Teva and received honoraria for speaking or consultation fees
from Almirall, Bayer Schering, Biogen Idec, Genzyme, GW Pharmaceuticals, Merck Serono,
Novartis, Sanofi-Aventis, Teva. He is also an external expert consultant of the European
Medicine Agency (EMA), and the principal investigator in clinical trials for Bayer
Schering, Biogen Idec, Merck Serono, Mitsubishi, Novartis, Roche, Sanofi-aventis,
Teva. His preclinical and clinical research was supported by grants from Bayer, Biogen,
MerckSerono, Novartis e Teva. Prof Comi has received honoraria for scientific lectures
from Biogen, Novartis, Teva, Genzyme, Bayer Schering, Merck Serono, Almirall. Dr Cottone
has received honoraria for advisory board activity from Bayer Schering. Prof Danni
has received honoraria for scientific lectures from Novartis, Merck-Serono, Biogen,
Teva. Dr Francia received a grant for advisory board activities from Almirall. Dr
Gajofatto has received support for travel to scientific meetings from Almirall, Biogen,
Genzyme, Merck-Serono and Novartis. Dr Gasperini received honoraria from Biogen, Genzyme,
Novartis, Merck Serono, Almirall, Teva. Dr Zaffaroni received honoraria from Biogen,
Genzyme, Novartis, Merck Serono, Almirall, Teva. Dr Petrucci has nothing to disclose.
Dr Signoriello has nothing to disclose. Dr Maniscalco received speaking and advisory
honoraria from Biogen, Novartis and Teva. Dr Spinicci has nothing to disclose. Dr.
Matta received honoraria for serving in the scientific advisory boards of Almirall,
Novartis, Biogen, Genzyme. Dr Mirabella received honoraria from Biogen, Genzyme, Novartis,
Merck Serono, Almirall, Teva. Dr Pedà has nothing to disclose. Dr Castelli has nothing
to disclose. Dr Rovaris received honoraria from Biogen, Genzyme, Novartis, Merck Serono,
Almirall, Teva. Dr Sessa received honoraria from Biogen, Genzyme, Novartis, Merck
Serono, Almirall, Teva. Dr Spitaleri has nothing to disclose. Dr Paolicelli has nothing
to disclose. Dr Granata has nothing to disclose. Prof Zappia has received compensation
for consulting services from Boehringer-Ingelheim, Lundbeck, Union ChimiqueBelge and
scientific grants from AIFA-AgenziaItaliana del Farmaco, Novartis, Lundbeck. Prof
Patti has received honoraria for scientific lectures and travel payment from Biogen,
Novartis, Teva, Genzyme, Bayer Schering, Merck Serono, Almirall. This does not alter
our adherence to PLOS ONE policies on sharing data and materials.
¶ The complete membership of the author group can be found in the Acknowledgments.
Author information
Article
Publisher ID:
PONE-D-17-04806
DOI: 10.1371/journal.pone.0180651
PMC ID: 5538735
PubMed ID: 28763462
SO-VID: 901ef5c9-9c60-4760-b345-967ead77f11d
Copyright © © 2017 Messina et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 6
February
2017
Date
accepted
: 19
June
2017
Page count
Figures: 2,
Tables: 2,
Pages: 10
Funding
The authors received no specific funding for this work.
Categories
Subject:
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