Journal ID (nlm-ta): medRxiv
Journal ID (publisher-id): MEDRXIV
Title:
medRxiv
Publisher:
Cold Spring Harbor Laboratory
Publication date
(Electronic):
29
June
2023
Electronic Location Identifier: 2023.06.23.23291827
Affiliations
[1
]Institute for Virology and Immunobiology, Julius-Maximilians-University of Würzburg,
Würzburg, Germany
[2
]Stanford Genome Technology Center, Stanford University School of Medicine, Stanford,
CA, USA
[3
]Rudolf Virchow Center, Center for Translational Bioimaging, Julius-Maximilians-University
of Würzburg, Germany
[4
]Institute for Medical Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany
[5
]Institute of Clinical Epidemiology and Biometry, Julius-Maximilians-University of
Würzburg, Würzburg, Germany.
[6
]Department of Clinical Research & Epidemiology, Comprehensive Heart Failure Center
and Department of Medicine I, University Hospital Würzburg, Würzburg, Germany
[7
]Internal Medicine Department I, University Hospital Schleswig-Holstein UKSH - Campus
Kiel, Kiel, Germany
[8
]University of Cologne, Faculty of Medicine and University Hospital Cologne, Department
of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf,
Germany
[9
]University Medicine Greifswald, Institute of Clinical Chemistry and Laboratory Medicine,
Greifswald, Germany
[10
]Charité - Universitätsmedizin Berlin and Berlin Institute of Health (BIH), Berlin,
Germany
[11
]Klinik für Rheumatologie, Universitätsklinikum Schleswig-Holstein, Lübeck
[12
]Departments of Medicine, Pediatrics, and Pathology, University of California, San
Diego School of Medicine, San Diego, USA
[13
]Institute for Behavioral Medicine Research (IBMR), The Ohio State University, Columbus,
Ohio, USA
[14
]Institute for Medical Data Sciences, University Hospital Würzburg, Würzburg
[15
]Clinical Trial Center, University Hospital Würzburg, Würzburg
Author notes
Author Contribution:
BKP conceived the idea, developed and supervised the project. ZL, CH, AG, AK carried
out majority of experiments; IMP carried out autophagosome work; SK carried out multivariate
and other statistical data analysis; AH, CN, VC, BA, TB, SC, JJV, OM, CS, KL, KT,
JR, FE, LS, PUH, SS, CM, FS, CS, NB, SK, GR contributed with patient recruitment,
sample collection, patient data management; MEA and MW contributed with important
reagents and experiments; AS and SL carried out mass spectrometry studies and related
data analysis, RN supervised mitochondrial experimental work, analyzed the data. BKP
drafted the manuscript with help from MEA. All other authors critically revised the
manuscript. All authors approved the submitted version.
Article
DOI: 10.1101/2023.06.23.23291827
PMC ID: 10327231
PubMed ID: 37425897
SO-VID: 8764a6a6-e9a6-4e8e-9262-632cc11e0bc8
License:
This work is licensed under a
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format
in unadapted form only, for noncommercial purposes only, and only so long as attribution
is given to the creator.
Funded by: Amar Foundation, USA for a career development grant (BKP), ME Research UK (BKP), Bundesministerium
für Bildung und Forschung (BMBF)
Award ID: 01EJ2204E
Funded by: National Institutes of Health (NIH/NIAID), USA, The infectious Diseases Society of
America (IDSA) Foundation, USA
Award ID: RO1AI084898-06
Funded by: National Pandemic Cohort Network (NAPKON)
Funded by: Network University Medicine
Award ID: 01KX2021
Funded by: federal state of Bavaria
Funded by: German Ministry of Research and Education, Comprehensive Heart Failure Centre Würzburg
Award ID: 01EO1004
Award ID: 01EO1504
Funded by: German Research Foundation (DFG), Comprehensive Research Center 1525 ‘Cardio-immune
interfaces’, Interdisciplinary Center for Clinical Research - IZKF Würzburg
Award ID: 453989101
