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<h5 class="section-title" id="d259632e255">Background:</h5>
<p id="P1">Decay products of radioactive materials may attach to ambient fine particles
and form
radioactive aerosol. Internal ionizing radiation source from inhaled radioactive aerosol
may contribute to the fine particulate matter (PM
<sub>2.5</sub>)-inflammation pathway. However, few studies in humans have examined
the associations.
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<h5 class="section-title" id="d259632e263">Objectives:</h5>
<p id="P2">To examine the associations between particle radioactivity and biomarkers
of oxidative
stress and inflammation among participants from the Framingham Offspring and Third
Generation cohorts.
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<h5 class="section-title" id="d259632e268">Methods:</h5>
<p id="P3">We included 3,996 participants who were not current smokers and lived within
50 km
from our central air pollution monitoring station. We estimated regional mean gross
beta radioactivity from monitors in the northeastern U.S. as a surrogate for ambient
radioactive particles, and calculated the 1- to 28-day moving averages. We used linear
regression models for fibrinogen, tumor necrosis factor α, interleukin-6, and myeloperoxidase
which were measured once, and linear mixed effect models for 8-epi-prostaglandin F
<sub>2α</sub>, C-reactive protein, intercellular adhesion molecule-1 (ICAM-1), monocyte
chemoattractant
protein-1 (MCP-1), P-selectin, and tumor necrosis factor receptor-2 that were measured
up to twice, adjusting for demographics, individual- and area-level socioeconomic
positions, time, meteorology, and PM
<sub>2.5</sub>. We also examined whether the associations differed by median age,
sex, diabetes
status, PM
<sub>2.5</sub> levels, and black carbon levels.
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<h5 class="section-title" id="d259632e282">Results:</h5>
<p id="P4">The mean age was 54 years and 54% were women. An interquartile range (3×10
<sup>−3</sup> pCi/m
<sup>3</sup>) higher beta radioactivity level at the 7-day moving average was associated
with
5.09% (95% CI: 0.92, 9.43), 2.65% (1.10, 4.22), and 4.71% (95% CI: 3.01, 6.44) higher
levels of interleukin-6, MCP-1, and P-selectin, but with 7.01% (95% CI: −11.64, −2.15)
and 2.70% (95% CI: −3.97, −1.42) lower levels of 8-epi-prostaglandin F
<sub>2α</sub> and ICAM-1, respectively.
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<h5 class="section-title" id="d259632e296">Conclusions:</h5>
<p id="P5">Regional mean particle radioactivity was positively associated with interleukin-6,
MCP-1, and P-selectin, but negatively with ICAM-1 and 8-epi-prostaglandin F
<sub>2α</sub> among our study participants.
</p>
</div><p id="P6">Associations between the 7-day moving average of regional mean gross
beta radioactivity
(per 3×10
<sup>−3</sup> pCi/m
<sup>3</sup>) and levels of oxidative stress and inflammation biomarkers among participants
from
the Framingham Offspring and Third Generation cohorts.
</p>