Downregulation of Lymphoid enhancer-binding factor 1 (LEF-1) expression (by immunohistochemistry and/ flow cytometry) in chronic Lymphocytic Leukemia with atypical immunophenotypic and cytologic features.

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Abstract

Lymphoid enhancer-binding factor 1 (LEF-1) overexpression has been recently remarkably reported in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and has shown utility in distinguishing CLL/SLL from other B-cell lymphomas. CLL has a well-defined immunophenotype, yet, some cases of CLL demonstrate atypical morphology/ phenotype reflected by low Matutes score (atypical CLL). Till date, LEF1 expression has not been systematically studied in cases of CLL with atypical features.

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Journal

Journal ID (iso-abbrev): Int J Lab Hematol

Title: International journal of laboratory hematology

Publisher: Wiley

ISSN (Electronic): 1751-553X

ISSN (Print): 1751-5521

Publication date (Electronic): Jun 2021

Volume: 43

Issue: 3

Affiliations

[1 ] Department of Laboratory Medicine and Pathology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

[2 ] Weill Cornell Medicine - Qatar, Doha, Qatar.

[3 ] Department of Clinical Pathology, National Cancer Institute, Cairo, Egypt.

[4 ] Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.

[5 ] Flow Cytometry Core Facility, interim Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

[6 ] Medical Research Center, Academic Health Systems, Hamad Medical Corporation, Doha, Qatar.

[7 ] Department of Hematology and Medical Oncology, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

[8 ] Nursing Department, Hazm Mebaireek General Hospital, Hamad Medical Corporation, Doha, Qatar.

Article

DOI: 10.1111/ijlh.13420

PubMed ID: 33314668

SO-VID: 8650c8fe-aadd-44bc-ab6d-395649c05ef8

History

Keywords: Immunohistochemistry,Flow cytometry,Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL),atypical CLL,Lymphoid enhancer-binding factor 1 (LEF-1)

Data availability:

Keywords: Immunohistochemistry, Flow cytometry, Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), atypical CLL, Lymphoid enhancer-binding factor 1 (LEF-1)

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