Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation.

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Abstract

We attempted to reproduce published studies that evaluated whether the following factors influence choroidal neovascularization (CNV) induced by laser photocoagulation in murine retinas: small interfering RNA (siRNA), cobra venom factor, complement factors C3 and C5, and complement receptor C5aR. In addition, we explored whether laser-induced CNV in mice was influenced by the vendor of origin of the animals.

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Journal

Journal ID (iso-abbrev): Invest Ophthalmol Vis Sci

Title: Investigative ophthalmology & visual science

Publisher: Association for Research in Vision and Ophthalmology (ARVO)

ISSN (Electronic): 1552-5783

ISSN (Print): 0146-0404

Publication date (Electronic): Sep 09 2014

Volume: 55

Issue: 10

Affiliations

[1 ] Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States.

Article

Publisher Item ID: iovs.14-15067

DOI: 10.1167/iovs.14-15067

PubMed ID: 25205860

SO-VID: 85dd85e0-c160-4795-bb05-8c34398eb0c0

History

Keywords: VEGF,choroidal neovascularization,laser,mice

Data availability:

Keywords: VEGF, choroidal neovascularization, laser, mice

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