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      Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

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          Abstract

          In order to simulate the cardiac function for a patient‐specific geometry, the generation of the computational mesh is crucially important. In practice, the input is typically a set of unprocessed polygonal surfaces coming either from a template geometry or from medical images. These surfaces need ad‐hoc processing to be suitable for a volumetric mesh generation. In this work we propose a set of new algorithms and tools aiming to facilitate the mesh generation process. In particular, we focus on different aspects of a cardiac mesh generation pipeline: (1) specific polygonal surface processing for cardiac geometries, like connection of different heart chambers or segmentation outputs; (2) generation of accurate boundary tags; (3) definition of mesh‐size functions dependent on relevant geometric quantities; (4) processing and connecting together several volumetric meshes. The new algorithms—implemented in the open‐source software vmtk—can be combined with each other allowing the creation of personalized pipelines, that can be optimized for each cardiac geometry or for each aspect of the cardiac function to be modeled. Thanks to these features, the proposed tools can significantly speed‐up the mesh generation process for a large range of cardiac applications, from single‐chamber single‐physics simulations to multi‐chambers multi‐physics simulations. We detail all the proposed algorithms motivating them in the cardiac context and we highlight their flexibility by showing different examples of cardiac mesh generation pipelines.

          Abstract

          1. We propose a set of algorithms and tools aiming to facilitate and speed‐up the mesh generation process for cardiac geometries.

          2. The main novelties regard the polygonal surface processing, the boundary tags definition, the mesh‐size definition, and the volumetric mesh processing.

          3. The new algorithms can be combined with each other to create personalized application‐specific pipelines.

          4. We demonstrate the robustness and the flexibility of the proposed tools through various examples on different kinds of cardiac geometries.

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          Gmsh: A 3-D finite element mesh generator with built-in pre- and post-processing facilities

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            An image-based modeling framework for patient-specific computational hemodynamics.

            We present a modeling framework designed for patient-specific computational hemodynamics to be performed in the context of large-scale studies. The framework takes advantage of the integration of image processing, geometric analysis and mesh generation techniques, with an accent on full automation and high-level interaction. Image segmentation is performed using implicit deformable models taking advantage of a novel approach for selective initialization of vascular branches, as well as of a strategy for the segmentation of small vessels. A robust definition of centerlines provides objective geometric criteria for the automation of surface editing and mesh generation. The framework is available as part of an open-source effort, the Vascular Modeling Toolkit, a first step towards the sharing of tools and data which will be necessary for computational hemodynamics to play a role in evidence-based medicine.
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              Whole-heart modeling: applications to cardiac electrophysiology and electromechanics.

              Recent developments in cardiac simulation have rendered the heart the most highly integrated example of a virtual organ. We are on the brink of a revolution in cardiac research, one in which computational modeling of proteins, cells, tissues, and the organ permit linking genomic and proteomic information to the integrated organ behavior, in the quest for a quantitative understanding of the functioning of the heart in health and disease. The goal of this review is to assess the existing state-of-the-art in whole-heart modeling and the plethora of its applications in cardiac research. General whole-heart modeling approaches are presented, and the applications of whole-heart models in cardiac electrophysiology and electromechanics research are reviewed. The article showcases the contributions that whole-heart modeling and simulation have made to our understanding of the functioning of the heart. A summary of the future developments envisioned for the field of cardiac simulation and modeling is also presented. Biophysically based computational modeling of the heart, applied to human heart physiology and the diagnosis and treatment of cardiac disease, has the potential to dramatically change 21st century cardiac research and the field of cardiology.
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                Author and article information

                Contributors
                marco.fedele@polimi.it
                Journal
                Int J Numer Method Biomed Eng
                Int J Numer Method Biomed Eng
                10.1002/(ISSN)2040-7947
                CNM
                International Journal for Numerical Methods in Biomedical Engineering
                John Wiley & Sons, Inc. (Hoboken, USA )
                2040-7939
                2040-7947
                28 January 2021
                April 2021
                : 37
                : 4 ( doiID: 10.1002/cnm.v37.4 )
                : e3435
                Affiliations
                [ 1 ] MOX, Department of Mathematics Politecnico di Milano Milan Italy
                [ 2 ] Institute of Mathematics École Polytechnique Fédérale de Lausanne Lausanne Switzerland
                Author notes
                [*] [* ] Correspondence

                Marco Fedele, MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy.

                Email: marco.fedele@ 123456polimi.it

                Author information
                https://orcid.org/0000-0001-5801-8260
                Article
                CNM3435
                10.1002/cnm.3435
                8244076
                33415829
                845150ad-c57e-438d-bf2f-a4a9acab17c8
                © 2021 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 01 January 2021
                : 02 October 2020
                : 02 January 2021
                Page count
                Figures: 18, Tables: 1, Pages: 34, Words: 21438
                Funding
                Funded by: European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme grant agreement No 740132, IHEART 2017‐2022, P.I. A. Quarteroni
                Categories
                Research Article ‐ Fundamental
                Research Article ‐ Fundamental
                Custom metadata
                2.0
                April 2021
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.0.2 mode:remove_FC converted:30.06.2021

                cardiac mesh generation,heart modeling,patient‐specific modeling,polygonal surface processing

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