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Dimethylthiourea ameliorates carbon tetrachloride-induced acute liver injury in ovariectomized mice
Satoru Mitazaki ,
Natsumi Kotajima ,
Sakiko Matsuda ,
Naruki Ida ,
Mina Iide ,
Shigeyoshi Honma ,
Miwako Suto ,
Naho Kato ,
Naohito Kuroda ,
Kouichi Hiraiwa ,
Makoto Yoshida ,
Sumiko Abe
August 2018
August 2018
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Abstract
<p class="first" id="d8738334e172">In order to clarify hepato-protective actions of
estrogen, we examined the progress
of carbon tetrachloride (CCl4)-induced acute liver injury (ALI) in sham and ovariectomized
(ovx) mice and the effects of dimethylthiourea (DMTU), a hydroxyl radical scavenger,
and meloxicam (Melo), a selective cox-2 inhibitor, on the development of CCl4-induced
ALI.
</p>