Evaluation of genetic risks of alkylating agents. II. Haemoglobin as a dose monitor

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Related collections

Most cited references 14

Record: found
Abstract: not found
Article: not found

A MICRO-BIURET METHOD FOR ESTIMATING PROTEINS.

R F ITZHAKI, D M GILL (1964)

0 comments Cited 69 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Evaluation of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide

L. Ethrenberg, K.D. Hiesche, S Osterman-Golkar … (1974)

0 comments Cited 44 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Nitrosamine-induced carcinogenesis. The alklylation of nucleic acids of the rat by N-methyl-N-nitrosourea, dimethylnitrosamine, dimethyl sulphate and methyl methanesulphonate.

P Swann, William Magee (1968)

1. N[(14)C]-Methyl-N-nitrosourea, [(14)C]dimethylnitrosamine, [(14)C]dimethyl sulphate and [(14)C]methyl methanesulphonate were injected into rats, and nucleic acids were isolated from several organs after various time-intervals. Radioactivity was detected in DNA and RNA, partly in major base components and partly as the methylated base, 7-methylguanine. 2. No 7-methylguanine was detected in liver DNA from normal untreated rats. 3. The specific radioactivity of 7-methylguanine isolated from DNA prepared from rats treated with [(14)C]dimethylnitrosamine was virtually the same as that of the dimethylnitrosamine injected. 4. The degree of methylation of RNA and DNA produced in various organs by each compound was determined, and expressed as a percentage of guanine residues converted into 7-methylguanine. With dimethylnitrosamine both nucleic acids were considerably more highly methylated in the liver (RNA, about 1% of guanine residues methylated; DNA, about 0.6% of guanine residues methylated) than in the other organs. Kidney nucleic acids were methylated to about one-tenth of the extent of those in the liver, lung showed slightly lower values and the other organs only very low values. N-Methyl-N-nitrosourea methylated nucleic acids to about the same extent in all the organs studied, the amount being about the same as that in the kidney after treatment with dimethylnitrosamine. In each case the RNA was more highly methylated than the DNA. Methyl methanesulphonate methylated the nucleic acids in several organs to about the same extent as N-methyl-N-nitrosourea, but the DNA was more highly methylated than the RNA. Dimethyl sulphate, even in toxic doses, gave considerably less methylation than N-methyl-N-nitrosourea in all the organs studied, the greatest methylation being in the brain. 5. The rate of removal of 7-methylguanine from DNA of kidneys from rats treated with dimethylnitrosamine was compared with the rate after treatment of rats with methyl methanesulphonate. No striking difference was found. 6. The results are discussed in connexion with the organ distribution of tumours induced by the compounds under study and in relation to the possible importance of alkylation of cellular components for the induction of cancer.

0 comments Cited 39 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Title: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Abbreviated Title: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Publisher: Elsevier BV

ISSN (Print): 00275107

Publication date Created: January 1976

Publication date (Print): January 1976

Volume: 34

Issue: 1

Pages: 1-10

Article

DOI: 10.1016/0027-5107(76)90256-6

SO-VID: 828236ac-96b8-431e-9e72-0b3b891225eb

License:

http://www.elsevier.com/tdm/userlicense/1.0/

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.