Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Resilience has been described in the psychosocial literature as the capacity to maintain or regain well-being during or after adversity. Physical resilience is a newer concept that is highly relevant to successful aging. Our objective was to characterize the emerging construct of resilience as it pertains to physical health in older adults, and to identify gaps and opportunities to advance research in this area.

Related collections

Most cited references 19

Record: found
Abstract: found
Article: not found

Quantification of biological aging in young adults.

Daniel W Belsky, Avshalom Caspi, Renate Houts … (2015)

Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young individuals. However, most human aging research examines older adults, many with chronic disease. As a result, little is known about aging in young humans. We studied aging in 954 young humans, the Dunedin Study birth cohort, tracking multiple biomarkers across three time points spanning their third and fourth decades of life. We developed and validated two methods by which aging can be measured in young adults, one cross-sectional and one longitudinal. Our longitudinal measure allows quantification of the pace of coordinated physiological deterioration across multiple organ systems (e.g., pulmonary, periodontal, cardiovascular, renal, hepatic, and immune function). We applied these methods to assess biological aging in young humans who had not yet developed age-related diseases. Young individuals of the same chronological age varied in their "biological aging" (declining integrity of multiple organ systems). Already, before midlife, individuals who were aging more rapidly were less physically able, showed cognitive decline and brain aging, self-reported worse health, and looked older. Measured biological aging in young adults can be used to identify causes of aging and evaluate rejuvenation therapies.

0 comments Cited 351 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Hormesis in aging.

Suresh Rattan (2007)

Hormesis in aging is represented by mild stress-induced stimulation of protective mechanisms in cells and organisms resulting in biologically beneficial effects. Single or multiple exposure to low doses of otherwise harmful agents, such as irradiation, food limitation, heat stress, hypergravity, reactive oxygen species and other free radicals have a variety of anti-aging and longevity-extending hormetic effects. Detailed molecular mechanisms that bring about the hormetic effects are being increasingly understood, and comprise a cascade of stress response and other pathways of maintenance and repair. Although the extent of immediate hormetic effects after exposure to a particular stress may only be moderate, the chain of events following initial hormesis leads to biologically amplified effects that are much larger, synergistic and pleiotropic. A consequence of hormetic amplification is an increase in the homeodynamic space of a living system in terms of increased defence capacity and reduced load of damaged macromolecules. Hormetic strengthening of the homeodynamic space provides wider margins for metabolic fluctuation, stress tolerance, adaptation and survival. Hormesis thus counter-balances the progressive shrinkage of the homeodynamic space, which is the ultimate cause of aging, diseases and death. Healthy aging may be achieved by hormesis through mild and periodic, but not severe or chronic, physical and mental challenges, and by the use of nutritional hormesis incorporating mild stress-inducing molecules called hormetins. The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in aging research and intervention.

0 comments Cited 135 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Book Chapter: not found

Qualitative Data Analysis for Applied Policy Research

Jane Ritchie, Liz Spencer (2002)

0 comments Cited 131 times – based on 0 reviews

Bookmark

All references

Author and article information

Journal

Title: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abbreviated Title: GERONA

Publisher: Oxford University Press (OUP)

ISSN (Print): 1079-5006

ISSN (Electronic): 1758-535X

Publication date Created: March 07 2016

Publication date (Print): April 29 2016

Volume: 71

Issue: 4

Pages: 489-495

Article

DOI: 10.1093/gerona/glv202

PMC ID: 5014191

PubMed ID: 26718984

SO-VID: 7f858876-f805-4179-b316-857e7a0efbb8

History

Data availability:

Comments

Comment on this article

scite_

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct

Read this article at

Abstract

Related collections

Cancer Immunotherapy

Most cited references 19

Quantification of biological aging in young adults.

Hormesis in aging.

Qualitative Data Analysis for Applied Policy Research

Author and article information

Journal

Article

History

Comments

Comment on this article

Similar content 2,024

Cited by 111

Most referenced authors 459