Effects of sintering temperature over 1,300 degrees C on the physical and compositional properties of porous hydroxyapatite foam.

Abstract

Porous hydroxyapatite (HAP) foam permits three-dimensional (3D) structure with fully interconnecting pores as well as excellent tissue response and good osteoconductivity. It is therefore thought to be a good candidate as scaffold material for bone regeneration and as a synthetic bone substitute material. To fabricate better porous HAP foam, improved physical and structural properties as well as higher osteoconductivity are desired. In the present study, the effects of sintering temperature on the physical and compositional properties of porous HAP foam were evaluated by employing high sintering temperature starting at 1,300 degrees C up to 1,550 degrees C. The mechanical strength of porous HAP foam increased with sintering temperature to reach the maximum value at 1,525 degrees C, then decreased slightly when sintering temperature was further increased to 1,550 degrees C. Alpha tricalcium phosphate (alpha-TCP) was formed, and thus the porous HAP foam became biphasic calcium phosphate. Biphasic calcium phosphate consisting of both alpha-TCP and HAP had been reported to show higher osteoconductivity than HAP alone. We therefore recommend 1,500-1,550 degrees C as the sintering temperature for porous HAP foam since this condition provided the most desirable physical properties with biphasic calcium phosphate composition.