Long-term actions of interleukin-1β on K+, Na+ and Ca2+ channel currents in small, IB4-positive dorsal root ganglion neurons; possible relevance to the etiology of neuropathic pain
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Abstract
<p class="first" id="d8971815e85">Excitation of dorsal root ganglion (DRG) neurons
by interleukin 1β (IL-1β) is implicated
in the onset of neuropathic pain. To understand its mechanism of action, isolectin
B4 positive (IB4+) DRG neurons were exposed to 100pM IL-1β for 5-6d. A reversible
increase in action potential (AP) amplitude reflected increased TTX-sensitive sodium
current (TTX-S INa). An irreversible increase in AP duration reflected decreased Ca2+-
sensitive K+ conductance (BK(Ca) channels). Different processes thus underlie regulation
of the two channel types. Since changes in AP shape facilitated Ca2+ influx, this
explains how IL-1β facilitates synaptic transmission in the dorsal horn; thereby provoking
pain.
</p>