Perspectives in the Cell-Based Therapies of Various Aspects of the Spinal Cord Injury-Associated Pathologies: Lessons from the Animal Models

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Abstract

Traumatic injury of the spinal cord (SCI) is a devastating neurological condition often leading to severe dysfunctions, therefore an improvement in clinical treatment for SCI patients is urgently needed. The potential benefits of transplantation of various cell types into the injured spinal cord have been intensively investigated in preclinical SCI models and clinical trials. Despite the many challenges that are still ahead, cell transplantation alone or in combination with other factors, such as artificial matrices, seems to be the most promising perspective. Here, we reviewed recent advances in cell-based experimental strategies supporting or restoring the function of the injured spinal cord with a particular focus on the regenerative mechanisms that could define their clinical translation.

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Author and article information

Contributors

Małgorzata Zawadzka: (View ORCID Profile)

Anna Kwaśniewska: (View ORCID Profile)

Krzysztof Miazga: (View ORCID Profile)

Urszula Sławińska: (View ORCID Profile)

Journal

Journal ID (publisher-id): CELLC6

Title: Cells

Abbreviated Title: Cells

Publisher: MDPI AG

ISSN (Electronic): 2073-4409

Publication date Created: November 2021

Publication date (Electronic): November 03 2021

Volume: 10

Issue: 11

Page: 2995

Article

DOI: 10.3390/cells10112995

PubMed ID: 34831217

SO-VID: 7d3cca94-67f4-443d-895b-768a9b5e3aa4

License:

https://creativecommons.org/licenses/by/4.0/

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