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Clinical-grade human neural stem cells promote reparative neovascularization in mouse models of hindlimb ischemia.
Rajesh Katare
1 ,
Paul Stroemer ,
Caroline Hicks ,
Lara Stevanato ,
Sara Patel ,
Randolph Corteling ,
Erik Miljan ,
Indira Vishnubhatla ,
John Sinden ,
Paolo Madeddu
Feb 2014
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Abstract
CTX0E03 (CTX) is a clinical-grade human neural stem cell (hNSC) line that promotes angiogenesis and neurogenesis in a preclinical model of stroke and is now under clinical development for stroke disability. We evaluated the therapeutic activity of intramuscular CTX hNSC implantation in murine models of hindlimb ischemia for potential translation to clinical studies in critical limb ischemia.
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