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      Influência da dieta hiperglicêmica e do diabetes aloxânico sobre a vitalidade do Schistosoma mansoni Sambon, 1907, em camundongos experimentalmente infectados Translated title: The influence of hyperglicemic diet and aloxanic diabetes on the vitality of Schistosoma mansoni in experimentally infected mice

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          Abstract

          Foram estudados alguns efeitos da dieta rica em açúcar e do diabetes aloxânico em Mus musculus albinos infectados com Schistosoma mansoni. Os resultados mostraram que: 1) o número de granulomas nos animais tratados pela aloxana foi significativamente menor do que nos animais não tratados por esta droga; 2) é possível que nos animais tratados pela aloxana exista algum fator que prejudique o desenvolvimento e a postura dos esquistossomos.

          Translated abstract

          Some effects of a sugar-rich diet and of the aloxanic diabetes in albino mice (Mus musculus) infected with Schistosoma mansoni were considered. The results showed: 1. the number of granulomata for the aloxane treated animals was significantly lower than the number for untreated animals. 2. one may, then, surmise that the aloxane treatment generates conditions that inhibits the development and oviposition of S. mansoni.

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          NOTES ON SUGAR DETERMINATION

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            CARBOHYDRATE METABOLISM OF SCHISTOSOMA MANSONI

            1. Schistosoma mansoni utilizes in 1 hour an amount of glucose equivalent to one-sixth to one-fifth of its dry weight. Over 80 per cent of the metabolized glucose is converted to lactic acid by this organism. 2. The rates of glucose utilization and of lactic acid production by S. mansoni are the same under aerobic and under anaerobic conditions. 3. A high rate of lactic acid production and the absence of a postanaerobic increase in the oxygen uptake differentiate S. mansoni from most other parasitic helminths whose metabolism has been studied. 4. Arsenite and p-chloromercuric benzoate inhibit in low concentrations the oxygen uptake and the rate of glycolysis of S. mansoni. This inhibition is not prevented or reversed by an excess of glutathione or of thioglycollate. 5. Fluoride inhibits the removal of glucose and the production of lactic acid by S. mansoni to the same degree. 6. Low concentrations of quinacrine (atabrine) do not affect the respiration or the carbohydrate metabolism of the schistosomes. 7. The inhibitory effect of aldehydes on the metabolism of S. mansoni has been measured. Among this group of compounds dl-glyceraldehyde and o-nitrobenzaldehyde are the most effective inhibitors of glycolysis. 8. In a concentration of 2.6 x 10–6 M (1:1,000,000) a cyanine dye inhibits almost completely the respiration of the schistosomes, but has no effect on their rate of glycolysis. The oxygen uptake of the worms is inhibited by fuadin to a greater degree than their rate of glycolysis. 2-methyl-1,4-napthoquinone is a much more effective inhibitor of glycolysis than of the respiration of S. mansoni. The latter compound interacts with plasma albumin and, therefore, its inhibitory action on the metabolism of the schistosomes is greatly reduced in human serum or plasma. 9. Evidence is discussed which indicates that, in contrast to glycolysis, respiratory metabolism is not essential for the survival of S. mansoni.
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              Notes of sugar determination

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                Author and article information

                Journal
                rsp
                Revista de Saúde Pública
                Rev. Saúde Pública
                Faculdade de Saúde Pública da Universidade de São Paulo (São Paulo, SP, Brazil )
                0034-8910
                1518-8787
                September 1978
                : 12
                : 3
                : 267-276
                Affiliations
                [01] Campinas SP orgnameUniversidade Estadual de Campinas orgdiv1Instituto de Biologia Brasil
                [02] São Luís MA orgnameUniversidade do Maranhão Brasil
                Article
                S0034-89101978000300002 S0034-8910(78)01200302
                10.1590/S0034-89101978000300002
                79116df7-6083-4c5a-b2c7-120b12d8cc11

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 13 April 1978
                : 09 November 1977
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 20, Pages: 10
                Product

                SciELO Brazil

                Self URI: Texto completo somente em PDF (PT)
                Categories
                Artigos Originais

                Schistosomiasis,Alloxan diabetes,Schistosoma mansoni,Esquistossomose mansônica,Diabetes aloxânico

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