Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis

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Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting patients’ quality of life and imposing heavy societal and economic burdens. Apoptosis of intestinal epithelial cells (IECs) has been considered an early event during the onset of UC and plays a crucial role in disease development. Thus, effectively inhibiting apoptosis of IECs is of critical significance for the clinical management of UC, presenting a potential direction for the research and development of pharmacotherapeutic agents. In recent years, research on the ameliorative effects of natural products on UC through inhibiting IECs apoptosis has attracted increasing attention and made remarkable achievements in ameliorating UC. In this review, we summarized the currently available research about the anti-apoptotic effects of natural products on UC and its mechanisms involving the death-receptor mediated pathway, mitochondrial-dependent pathway, ERS-mediated pathway, MAPK-mediated pathway, NF-κB mediated pathway, P13k/Akt pathway, JAK/STAT3 pathway, and NLRP3/ASC/Caspase-1 pathway. Hopefully, this review may yield useful information about the anti-apoptotic effects of natural products on UC and their potential molecular mechanisms and provide helpful insights for further investigations.

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Most cited references 124

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The process of programmed cell death, or apoptosis, is generally characterized by distinct morphological characteristics and energy-dependent biochemical mechanisms. Apoptosis is considered a vital component of various processes including normal cell turnover, proper development and functioning of the immune system, hormone-dependent atrophy, embryonic development and chemical-induced cell death. Inappropriate apoptosis (either too little or too much) is a factor in many human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. The ability to modulate the life or death of a cell is recognized for its immense therapeutic potential. Therefore, research continues to focus on the elucidation and analysis of the cell cycle machinery and signaling pathways that control cell cycle arrest and apoptosis. To that end, the field of apoptosis research has been moving forward at an alarmingly rapid rate. Although many of the key apoptotic proteins have been identified, the molecular mechanisms of action or inaction of these proteins remain to be elucidated. The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptosis in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptosis.

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Author and article information

Contributors

Chenhao Liu: URI : https://loop.frontiersin.org/people/1539172/overview

Yiwei Zeng: URI : https://loop.frontiersin.org/people/1531851/overview

Journal

Journal ID (nlm-ta): Front Pharmacol

Journal ID (iso-abbrev): Front Pharmacol

Journal ID (publisher-id): Front. Pharmacol.

Title: Frontiers in Pharmacology

Publisher: Frontiers Media S.A.

ISSN (Electronic): 1663-9812

Publication date (Electronic): 31 January 2022

Publication date Collection: 2022

Volume: 13

Electronic Location Identifier: 806148

Affiliations

[1] ¹ School of Basic Medical Sciences , Chengdu University of Traditional Chinese Medicine , Chengdu, China

[2] ² School of Acupuncture-Moxibustion and Tuina , Chengdu University of Traditional Chinese Medicine , Chengdu, China

Author notes

Edited by: Xin Luan, Shanghai University of Traditional Chinese Medicine, China

Reviewed by: Songqi Tang, Hainan Medical University, China

Fengjie Zheng, Beijing University of Chinese Medicine, China

*Correspondence: Yi Liu, tcmly@ 123456163.com

[ † ]

ORCID: Chenhao Liu, orcid.org/0000-0003-2563-2760; Yiwei Zeng, orcid.org/0000-0002-7042-2503

[ ‡ ]

These authors have contributed equally to this work

This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology

Article

Publisher ID: 806148

DOI: 10.3389/fphar.2022.806148

PMC ID: 8841338

PubMed ID: 35173617

SO-VID: 73046db1-b043-4220-bd78-998d53439385

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

History

Date received : 31 October 2021

Date accepted : 10 January 2022

Funding

Funded by: State Administration of Traditional Chinese Medicine of the People’s Republic of China , doi 10.13039/501100005891;

Natural Products Modulate Cell Apoptosis: A Promising Way for the Treatment of Ulcerative Colitis

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Karger: Gastroenterology

Most cited references 124

Apoptosis: a review of programmed cell death.

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies.

The unfolded protein response: controlling cell fate decisions under ER stress and beyond.

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