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      Fighting the unbearable lightness of neglecting kidney health: the decade of the kidney *

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          Abstract

          A brief comprehensive overview is provided of the elements constituting the burden of kidney disease [chronic kidney disease (CKD) and acute kidney injury]. This publication can be used for advocacy, emphasizing the importance and urgency of reducing this heavy and rapidly growing burden. Kidney diseases contribute to significant physical limitations, loss of quality of life, emotional and cognitive disorders, social isolation and premature death. CKD affects close to 100 million Europeans, with 300 million being at risk, and is projected to become the fifth cause of worldwide death by 2040. Kidney disease also imposes financial burdens, given the costs of accessing healthcare and inability to work. The extrapolated annual cost of all CKD is at least as high as that for cancer or diabetes. In addition, dialysis treatment of kidney diseases imposes environmental burdens by necessitating high energy and water consumption and producing plastic waste. Acute kidney injury is associated with further increases in global morbidity, mortality and economic burden. Yet investment in research for treatment of kidney disease lags behind that of other diseases. This publication is a call for European investment in research for kidney health. The innovations generated should mirror the successful European Union actions against cancer over the last 30 years. It is also a plea to nephrology professionals, patients and their families, caregivers and kidney health advocacy organizations to draw, during the Decade of the Kidney (2020–30), the attention of authorities to realize changes in understanding, research and treatment of kidney disease.

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          Clinical Characteristics of Coronavirus Disease 2019 in China

          Abstract Background Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients. Methods We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death. Results The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission. Conclusions During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.)
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            Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention

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              Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

              There is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19).
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                Author and article information

                Journal
                Clin Kidney J
                Clin Kidney J
                ckj
                Clinical Kidney Journal
                Oxford University Press
                2048-8505
                2048-8513
                July 2021
                20 April 2021
                20 April 2021
                : 14
                : 7
                : 1719-1730
                Affiliations
                [1 ] Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital , Ghent, Belgium
                [2 ] European Kidney Health Alliance , Brussels, Belgium
                [3 ] Department of Public Health and Primary Care, Ghent University , Ghent, Belgium
                [4 ] Department of Public Health, Interuniversity Center for Health Economics Research (I-CHER), Free University of Brussels , Brussels, Belgium
                [5 ] Division of Nephrology, Department of Medicine, University of Alberta , Edmonton, Canada
                [6 ] Istituto di Richerche Farmcologiche Mario Negri RICCS , Milan, Italy
                [7 ] European Kidney Patient Federation (EKPF) , Dublin, Ireland
                [8 ] Spanish Kidney Patient Federation (ALCER) , Madrid, Spain
                [9 ] Department of Nephrology, University Medical Center Groningen, University of Groningen , Groningen, The Netherlands
                [10 ] Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital , Ghent, Belgium
                [11 ] Department of Paediatrics and Child Health, University of Cape Town , Cape Town, South Africa
                [12 ] Renal Division, Brigham and Women’s Hospital , Boston, MA, USA
                [13 ] European Dialysis and Transplant Nurses Association–European Renal Care Association (EDTNA/ERCA) , Nidwalden, Switzerland
                [14 ] Dutch Kidney Foundation , Bussum, the Netherlands
                [15 ] Department of Internal Medicine I, Nephrology Section, Würzburg University, Würzburg University Hospital , Würzburg, Germany
                [16 ] IMEC Eindhoven , Eindhoven, the Netherlands
                [17 ] Department of Nephrology and Hypertension, University Medical Center Utrecht , Utrecht, the Netherlands
                Author notes
                Correspondence to: Raymond Vanholder; E-mail: Raymond.vanholder@ 123456ugent.be
                Author information
                https://orcid.org/0000-0003-2633-1636
                Article
                sfab070
                10.1093/ckj/sfab070
                8243275
                34221379
                70758b83-d8c1-4835-809e-8a6ac882cab8
                © The Author(s) 2021. Published by Oxford University Press on behalf of ERA-EDTA.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                : 10 March 2021
                : 16 March 2021
                Page count
                Pages: 12
                Categories
                Ckj Reviews
                AcademicSubjects/MED00340

                Nephrology
                acute kidney injury,chronic kidney disease,dialysis,epidemiology,environment,health economy,kidney transplantation,mortality,non-communicable diseases,peritoneal dialysis

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