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      Trends in Surgical Treatment of Femoral Head Osteonecrosis in South Korea: An Analysis Using Nationwide Claims Database

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          Abstract

          Background

          Osteonecrosis of the femoral head (ONFH) involves young or middle-aged adults, and its incidence is increasing along with increasing use of steroids in the management of organ transplantation and adjuvant therapy for malignant neoplasms. To date, no pharmacological agent has been proven to prevent or retard the progression of ONFH, and surgical procedures including joint preservation procedures and hip arthroplasties are main treatments for the disease. Although ONFH is the most common or second most common disease for hip arthroplasty in East Asian countries, the trend of surgical procedures in this region remains unknown. Thus, we evaluated trends in surgical treatment of the disease in South Korea.

          Methods

          We identified patients with ONFH from the Korean Health Insurance Review and Assessment (HIRA) database, a nationwide medical claims database of South Korea, between January 2007 and December 2018 and calculated the proportions of following surgical procedures at each year: total hip arthroplasty (THA), hemiarthroplasty (HA), core decompression/multiple drilling, femoral osteotomy, and vascularized bone grafting.

          Results

          The total number of procedures increased from 3,824 in 2007 to 6,929 in 2018. Overall, the rate of THA (86%) was far greater than other procedures. From 2007 to 2018, the percentage of THA among the procedures increased from 80% to 91%, while that of joint preservation procedures decreased from 11% to 5%.

          Conclusions

          The total number of surgical procedures performed for ONFH increased and the percentage of THA increased, while that of joint preservation procedures decreased from 2007 to 2018 in South Korea.

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          Most cited references30

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          Non-traumatic avascular necrosis of the femoral head.

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            Nontraumatic necrosis of bone (osteonecrosis).

            H Mankin (1992)
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              Current concepts on osteonecrosis of the femoral head.

              It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. The lack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging (MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures (FHSP) and femoral head replacement procedures (FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated.
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                Author and article information

                Journal
                Clin Orthop Surg
                Clin Orthop Surg
                CIOS
                Clinics in Orthopedic Surgery
                The Korean Orthopaedic Association
                2005-291X
                2005-4408
                December 2022
                28 September 2022
                : 14
                : 4
                : 500-506
                Affiliations
                [* ]Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
                []Department of Orthopedic Surgery, Seoul National University Hospital, Seoul, Korea.
                []Data Science Team, Pharmaceutical. Co., Ltd., Seoul, Korea.
                [§ ]Department of Biostatistics, Yonsei University Wonju College of Medicine, Wonju, Korea.
                []Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul, Korea.
                Author notes
                Correspondence to: Jung-Wee Park, MD. Department of Orthopedic Surgery, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam 13620, Korea. Tel: +82-31-787-7204, Fax: +82-31-787-4056, jwepark@ 123456gmail.com

                Jung-Wee Park and Hong-Seok Kim contributed equally to this work.

                Author information
                https://orcid.org/0000-0002-4515-1895
                https://orcid.org/0000-0002-9524-7019
                https://orcid.org/0000-0001-6019-6912
                https://orcid.org/0000-0002-5482-1758
                https://orcid.org/0000-0001-6564-4294
                https://orcid.org/0000-0001-5251-2911
                Article
                10.4055/cios22027
                9715925
                36518932
                6f5a8f13-3776-4595-a1c3-6caa929bad42
                Copyright © 2022 by The Korean Orthopaedic Association

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 16 January 2022
                : 16 February 2022
                : 16 February 2022
                Funding
                Funded by: Seoul National University Bundang Hospital, CrossRef https://doi.org/10.13039/100016275;
                Award ID: 02-2021-0025
                Categories
                Original Article

                Surgery
                hip,osteonecrosis,avascular necrosis,therapy,trends
                Surgery
                hip, osteonecrosis, avascular necrosis, therapy, trends

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