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      Annual Research Review: The impact of Covid‐19 on psychopathology in children and young people worldwide: systematic review of studies with pre‐ and within‐pandemic data

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          Abstract

          Background

          The high volume and pace of research has posed challenges to researchers, policymakers and practitioners wanting to understand the overall impact of the pandemic on children and young people's mental health. We aimed to search for and review the evidence from epidemiological studies to answer the question: how has mental health changed in the general population of children and young people?

          Methods

          Four databases (Medline, CINAHL, EMBASE and PsychINFO) were searched in October 2021, with searches updated in February 2022. We aimed to identify studies of children or adolescents with a mean age of 18 years or younger at baseline, that reported change on a validated mental health measure from prepandemic to during the pandemic. Abstracts and full texts were double‐screened against inclusion criteria and quality assessed using a risk of bias tool. Studies were narratively synthesised, and meta‐analyses were performed where studies were sufficiently similar.

          Results

          6917 records were identified, and 51 studies included in the review. Only four studies had a rating of high quality. Studies were highly diverse in terms of design, setting, timing in relation to the pandemic, population, length of follow‐up and choice of measure. Methodological heterogeneity limited the potential to conduct meta‐analyses across studies. Whilst the evidence suggested a slight deterioration on some measures, overall, the findings were mixed, with no clear pattern emerging.

          Conclusions

          Our findings highlight the need for a more harmonised approach to research in this field. Despite the sometimes‐inconsistent results of our included studies, the evidence supports existing concerns about the impact of Covid‐19 on children's mental health and on services for this group, given that even small changes can have a significant impact on provision at population level. Children and young people must be prioritised in pandemic recovery, and explicitly considered in planning for any future pandemic response.

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          Most cited references147

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          A brief measure for assessing generalized anxiety disorder: the GAD-7.

          Generalized anxiety disorder (GAD) is one of the most common mental disorders; however, there is no brief clinical measure for assessing GAD. The objective of this study was to develop a brief self-report scale to identify probable cases of GAD and evaluate its reliability and validity. A criterion-standard study was performed in 15 primary care clinics in the United States from November 2004 through June 2005. Of a total of 2740 adult patients completing a study questionnaire, 965 patients had a telephone interview with a mental health professional within 1 week. For criterion and construct validity, GAD self-report scale diagnoses were compared with independent diagnoses made by mental health professionals; functional status measures; disability days; and health care use. A 7-item anxiety scale (GAD-7) had good reliability, as well as criterion, construct, factorial, and procedural validity. A cut point was identified that optimized sensitivity (89%) and specificity (82%). Increasing scores on the scale were strongly associated with multiple domains of functional impairment (all 6 Medical Outcomes Study Short-Form General Health Survey scales and disability days). Although GAD and depression symptoms frequently co-occurred, factor analysis confirmed them as distinct dimensions. Moreover, GAD and depression symptoms had differing but independent effects on functional impairment and disability. There was good agreement between self-report and interviewer-administered versions of the scale. The GAD-7 is a valid and efficient tool for screening for GAD and assessing its severity in clinical practice and research.
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            The PHQ-9: validity of a brief depression severity measure.

            While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity. The Patient Health Questionnaire (PHQ) is a self-administered version of the PRIME-MD diagnostic instrument for common mental disorders. The PHQ-9 is the depression module, which scores each of the 9 DSM-IV criteria as "0" (not at all) to "3" (nearly every day). The PHQ-9 was completed by 6,000 patients in 8 primary care clinics and 7 obstetrics-gynecology clinics. Construct validity was assessed using the 20-item Short-Form General Health Survey, self-reported sick days and clinic visits, and symptom-related difficulty. Criterion validity was assessed against an independent structured mental health professional (MHP) interview in a sample of 580 patients. As PHQ-9 depression severity increased, there was a substantial decrease in functional status on all 6 SF-20 subscales. Also, symptom-related difficulty, sick days, and health care utilization increased. Using the MHP reinterview as the criterion standard, a PHQ-9 score > or =10 had a sensitivity of 88% and a specificity of 88% for major depression. PHQ-9 scores of 5, 10, 15, and 20 represented mild, moderate, moderately severe, and severe depression, respectively. Results were similar in the primary care and obstetrics-gynecology samples. In addition to making criteria-based diagnoses of depressive disorders, the PHQ-9 is also a reliable and valid measure of depression severity. These characteristics plus its brevity make the PHQ-9 a useful clinical and research tool.
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                Author and article information

                Contributors
                t.newlove-delgado@exeter.ac.uk
                Journal
                J Child Psychol Psychiatry
                J Child Psychol Psychiatry
                10.1111/(ISSN)1469-7610
                JCPP
                Journal of Child Psychology and Psychiatry, and Allied Disciplines
                John Wiley and Sons Inc. (Hoboken )
                0021-9630
                1469-7610
                24 November 2022
                April 2023
                : 64
                : 4 , Annual Research Review 2023 ( doiID: 10.1111/jcpp.v64.4 )
                : 611-640
                Affiliations
                [ 1 ] University of Exeter Medical School University of Exeter Exeter UK
                [ 2 ] Department of Psychiatry University of Cambridge Cambridge UK
                [ 3 ] NIHR Applied Research Collaboration South West Peninsula (PenARC) Exeter UK
                Author notes
                [*] [* ] Correspondence

                Tamsin Newlove‐Delgado, Room 2.05a, South Cloisters, University of Exeter Medical School, Heavitree Road, Exeter EX2 2LU, UK; Email: t.newlove-delgado@ 123456exeter.ac.uk

                Author information
                https://orcid.org/0000-0002-5192-3724
                https://orcid.org/0000-0002-2903-6264
                https://orcid.org/0000-0001-5295-4904
                Article
                JCPP13716 JCPP-ARR-2022-00253.R1
                10.1111/jcpp.13716
                10952503
                36421049
                6cb2aa2a-17a0-40e3-b9f4-b8ebb08a6450
                © 2022 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 02 September 2022
                Page count
                Figures: 13, Tables: 1, Pages: 640, Words: 25601
                Funding
                Funded by: NIHR , doi 10.13039/100006662;
                Award ID: NIHR300591
                Award ID: NIHR300056
                Funded by: UK Research and Innovation (Medical Research Council) , doi 10.13039/501100007155;
                Award ID: MR/V027751/1
                Categories
                Annual Research Review
                Annual Research Review
                Custom metadata
                2.0
                April 2023
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.3.9 mode:remove_FC converted:20.03.2024

                Clinical Psychology & Psychiatry
                covid‐19,pandemic,children,young people,mental health
                Clinical Psychology & Psychiatry
                covid‐19, pandemic, children, young people, mental health

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