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A bioinorganic view of Alzheimer's disease: when misplaced metal ions (re)direct the electrons to the wrong target.

Author(s): Peter Faller, Christelle Hureau

Publication date: 2012-12-07

Journal: Chemistry (Weinheim an Der Bergstrasse, Germany)

Keywords: Alzheimer Disease, metabolism, pathology, Brain, Electrons, Humans, Ions, chemistry, Metals, Neurodegenerative Diseases, Oxidation-Reduction, Oxidative Stress

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Abstract

Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimer's disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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PubMed ID:: 23180511

DOI:: 10.1002/chem.201202697

ScienceOpen disciplines: Chemistry

Keywords: Alzheimer Disease,metabolism,pathology,Brain,Electrons,Humans,Ions,chemistry,Metals,Neurodegenerative Diseases,Oxidation-Reduction,Oxidative Stress

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ScienceOpen disciplines: Chemistry

Keywords: Alzheimer Disease, metabolism, pathology, Brain, Electrons, Humans, Ions, chemistry, Metals, Neurodegenerative Diseases, Oxidation-Reduction, Oxidative Stress

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