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      Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children

      1 , 2 , 3 , 3 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , , 19 , 20 , 21 , 22 , 8 , 23 , 24 , 25 , 26 , 27 , 28 , 23 , 29 , 27 , 30 , 31 , 20 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 36 , 39 , 40
      JAMA Pediatrics
      American Medical Association (AMA)

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          Abstract

          Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing public health concern because epidemiologic data indicate a marked increase in the number of emergency department visits for mTBI over the past decade. However, no evidence-based clinical guidelines have been developed to date for diagnosing and managing pediatric mTBI in the United States. To provide a guideline based on a previous systematic review of the literature to obtain and assess evidence toward developing clinical recommendations for health care professionals related to the diagnosis, prognosis, and management/treatment of pediatric mTBI. The Centers for Disease Control and Prevention (CDC) National Center for Injury Prevention and Control Board of Scientific Counselors, a federal advisory committee, established the Pediatric Mild Traumatic Brain Injury Guideline Workgroup. The workgroup drafted recommendations based on the evidence that was obtained and assessed within the systematic review, as well as related evidence, scientific principles, and expert inference. This information includes selected studies published since the evidence review was conducted that were deemed by the workgroup to be relevant to the recommendations. The dates of the initial literature search were January 1, 1990, to November 30, 2012, and the dates of the updated literature search were December 1, 2012, to July 31, 2015. The CDC guideline includes 19 sets of recommendations on the diagnosis, prognosis, and management/treatment of pediatric mTBI that were assigned a level of obligation (ie, must, should, or may) based on confidence in the evidence. Recommendations address imaging, symptom scales, cognitive testing, and standardized assessment for diagnosis; history and risk factor assessment, monitoring, and counseling for prognosis; and patient/family education, rest, support, return to school, and symptom management for treatment. This guideline identifies the best practices for mTBI based on the current evidence; updates should be made as the body of evidence grows. In addition to the development of the guideline, CDC has created user-friendly guideline implementation materials that are concise and actionable. Evaluation of the guideline and implementation materials is crucial in understanding the influence of the recommendations.

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          Most cited references112

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          Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study

          Summary Background Although CT scans are very useful clinically, potential cancer risks exist from associated ionising radiation, in particular for children who are more radiosensitive than adults. We aimed to assess the excess risk of leukaemia and brain tumours after CT scans in a cohort of children and young adults. Methods In our retrospective cohort study, we included patients without previous cancer diagnoses who were first examined with CT in National Health Service (NHS) centres in England, Wales, or Scotland (Great Britain) between 1985 and 2002, when they were younger than 22 years of age. We obtained data for cancer incidence, mortality, and loss to follow-up from the NHS Central Registry from Jan 1, 1985, to Dec 31, 2008. We estimated absorbed brain and red bone marrow doses per CT scan in mGy and assessed excess incidence of leukaemia and brain tumours cancer with Poisson relative risk models. To avoid inclusion of CT scans related to cancer diagnosis, follow-up for leukaemia began 2 years after the first CT and for brain tumours 5 years after the first CT. Findings During follow-up, 74 of 178 604 patients were diagnosed with leukaemia and 135 of 176 587 patients were diagnosed with brain tumours. We noted a positive association between radiation dose from CT scans and leukaemia (excess relative risk [ERR] per mGy 0·036, 95% CI 0·005–0·120; p=0·0097) and brain tumours (0·023, 0·010–0·049; p<0·0001). Compared with patients who received a dose of less than 5 mGy, the relative risk of leukaemia for patients who received a cumulative dose of at least 30 mGy (mean dose 51·13 mGy) was 3·18 (95% CI 1·46–6·94) and the relative risk of brain cancer for patients who received a cumulative dose of 50–74 mGy (mean dose 60·42 mGy) was 2·82 (1·33–6·03). Interpretation Use of CT scans in children to deliver cumulative doses of about 50 mGy might almost triple the risk of leukaemia and doses of about 60 mGy might triple the risk of brain cancer. Because these cancers are relatively rare, the cumulative absolute risks are small: in the 10 years after the first scan for patients younger than 10 years, one excess case of leukaemia and one excess case of brain tumour per 10 000 head CT scans is estimated to occur. Nevertheless, although clinical benefits should outweigh the small absolute risks, radiation doses from CT scans ought to be kept as low as possible and alternative procedures, which do not involve ionising radiation, should be considered if appropriate. Funding US National Cancer Institute and UK Department of Health.
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            The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk.

            Increased use of computed tomography (CT) in pediatrics raises concerns about cancer risk from exposure to ionizing radiation. To quantify trends in the use of CT in pediatrics and the associated radiation exposure and cancer risk. Retrospective observational study. Seven US health care systems. The use of CT was evaluated for children younger than 15 years of age from 1996 to 2010, including 4 857 736 child-years of observation. Radiation doses were calculated for 744 CT scans performed between 2001 and 2011. Rates of CT use, organ and effective doses, and projected lifetime attributable risks of cancer. RESULTS The use of CT doubled for children younger than 5 years of age and tripled for children 5 to 14 years of age between 1996 and 2005, remained stable between 2006 and 2007, and then began to decline. Effective doses varied from 0.03 to 69.2 mSv per scan. An effective dose of 20 mSv or higher was delivered by 14% to 25% of abdomen/pelvis scans, 6% to 14% of spine scans, and 3% to 8% of chest scans. Projected lifetime attributable risks of solid cancer were higher for younger patients and girls than for older patients and boys, and they were also higher for patients who underwent CT scans of the abdomen/pelvis or spine than for patients who underwent other types of CT scans. For girls, a radiation-induced solid cancer is projected to result from every 300 to 390 abdomen/pelvis scans, 330 to 480 chest scans, and 270 to 800 spine scans, depending on age. The risk of leukemia was highest from head scans for children younger than 5 years of age at a rate of 1.9 cases per 10 000 CT scans. Nationally, 4 million pediatric CT scans of the head, abdomen/pelvis, chest, or spine performed each year are projected to cause 4870 future cancers. Reducing the highest 25% of doses to the median might prevent 43% of these cancers. The increased use of CT in pediatrics, combined with the wide variability in radiation doses, has resulted in many children receiving a high-dose examination. Dose-reduction strategies targeted to the highest quartile of doses could dramatically reduce the number of radiation-induced cancers.
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              Clinical Risk Score for Persistent Postconcussion Symptoms Among Children With Acute Concussion in the ED.

              Approximately one-third of children experiencing acute concussion experience ongoing somatic, cognitive, and psychological or behavioral symptoms, referred to as persistent postconcussion symptoms (PPCS). However, validated and pragmatic tools enabling clinicians to identify patients at risk for PPCS do not exist.
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                Author and article information

                Journal
                JAMA Pediatrics
                JAMA Pediatr
                American Medical Association (AMA)
                2168-6203
                November 01 2018
                November 05 2018
                : 172
                : 11
                : e182853
                Affiliations
                [1 ]Stanford University School of Medicine, Stanford, California
                [2 ]University of Calgary, Calgary, Alberta, Canada
                [3 ]Division of Unintentional Injury Prevention, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention (CDC), Atlanta, Georgia
                [4 ]Children’s National Health System, George Washington University School of Medicine, Washington, DC
                [5 ]Goodman Campbell Brain and Spine, Indianapolis, Indiana
                [6 ]Cleveland Clinic, Cleveland, Ohio
                [7 ]Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
                [8 ]The University of California, Los Angeles (UCLA) Steve Tisch BrainSPORT Program, UCLA Mattel Children’s Hospital, David Geffen School of Medicine at UCLA, Los Angeles
                [9 ]University of Florida Health Science Center, Jacksonville
                [10 ]Center for Neuropsychological Services, Kaiser Permanente, Roseville, California
                [11 ]Emory University School of Medicine, Atlanta, Georgia
                [12 ]Icahn School of Medicine at Mount Sinai, New York, New York
                [13 ]Sports Concussion Center of New Jersey, Princeton
                [14 ]Rocky Mountain Hospital for Children, Denver, Colorado
                [15 ]Children’s Learning Institute, Department of Pediatrics, University of Texas (UT) Health Science Center at Houston
                [16 ]Massachusetts General Hospital, Harvard University, Boston
                [17 ]University Health Services, Princeton University, Princeton, New Jersey
                [18 ]Loma Linda University Health, Loma Linda, California
                [19 ]Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio
                [20 ]University of Washington School of Medicine, Seattle
                [21 ]St Louis Children’s Hospital, St Louis, Missouri
                [22 ]University of Utah, Salt Lake City
                [23 ]Children's Hospital of Philadelphia, Raymond and Ruth Perelman School of Medicine, University of Pennsylvania, Philadelphia
                [24 ]The University of North Carolina at Chapel Hill
                [25 ]John H. Stroger, Jr Hospital of Cook County (formerly Cook County Hospital), Chicago, Illinois
                [26 ]Vanderbilt University School of Medicine, Nashville, Tennessee
                [27 ]University of Pittsburgh Medical Center Sports Medicine Concussion Program, Pittsburgh, Pennsylvania
                [28 ]Nationwide Children’s Hospital Research Institute, Columbus, Ohio
                [29 ]Jameson Crane Sports Medicine Institute, School of Health and Rehabilitation Sciences, The Ohio State University Wexner Medical Center, Columbus
                [30 ]Children’s Hospital Colorado, Aurora
                [31 ]Nicklaus Children’s Hospital, University of Miami Miller School of Medicine, Miami, Florida
                [32 ]Department of Pediatric Neurosurgery, St Joseph’s Children’s Hospital, Tampa, Florida
                [33 ]University of California, San Diego
                [34 ]Vanguard Communications, Washington, DC
                [35 ]The National Association of State EMS Officials, Washington, Iowa
                [36 ]Social Marketing Group, ICF, Rockville, Maryland
                [37 ]American Academy of Neurology, Minneapolis, Minnesota
                [38 ]University of Kansas Medical Center, Kansas City
                [39 ]University of Virginia School of Medicine, Charlottesville
                [40 ]Penn State University Milton S. Hershey Medical Center, Hershey, Pennsylvania
                Article
                10.1001/jamapediatrics.2018.2853
                7006878
                30193284
                689f4563-aa72-41ce-9a07-9c729598efd5
                © 2018
                History

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